Sponsor-Dedicated Global Senior Project Manager – Early Development (Remote, UK)
Updated: February 3, 2026
Location: United Kingdom (Remote)
Primary Hub: London, UK
Job ID: 25105387
Employment Type: Full-Time | Sponsor-Dedicated | Global Role
About Syneos Health
Syneos Health® is a globally integrated biopharmaceutical solutions organization focused on accelerating the development and delivery of innovative therapies. By integrating clinical development, medical affairs, and commercial expertise, Syneos Health helps sponsors navigate complex development landscapes while keeping patients at the center of every decision. With more than 29,000 professionals across 110+ countries, Syneos Health delivers operational excellence at global scale.
Role Overview
The Sponsor-Dedicated Global Senior Project Manager – Early Development provides strategic and operational leadership for early-phase (Phase I–II) clinical trials. This role is responsible for global oversight of site management, clinical monitoring (on-site, remote, and central), and trial execution activities, ensuring compliance with protocol, GCP, regulatory requirements, and sponsor expectations. Acting as a senior escalation point, this position plays a critical role in risk management, stakeholder communication, and delivery of high-quality clinical outcomes across global studies.
Key Responsibilities
Clinical Trial Oversight & Delivery
Provide end-to-end oversight of site management and clinical monitoring activities from site activation through closeout.
Ensure patient safety, data integrity, and compliance with protocol, ICH-GCP, SOPs, and country-specific regulations.
Support patient recruitment activities, investigator payments, and site-level operational deliverables as required.
Identify critical data, processes, and protocol execution risks, contributing to Risk Assessment and Categorization Tool (RACT) development and mitigation planning.
Risk Management & Strategic Leadership
Review study scope of work, budgets, and protocols to ensure clinical teams understand contractual obligations and delivery parameters.
Utilize operational data, metrics, and reports to proactively identify risks to timelines, quality, and budget.
Escalate out-of-scope activities, delivery risks, and performance issues to project leadership and sponsors.
Develop and implement effective risk mitigation strategies and present updates in key governance forums, including Kick-Off Meetings.
Stakeholder & Site Engagement
Serve as a senior escalation point for investigator sites and sponsor communications, including direct interaction with principal investigators when required.
Support conflict resolution and performance oversight, including accompanying CRAs during site visits when necessary.
Collaborate cross-functionally with Study Start-Up, Data Management, Patient Recruitment, Medical Monitoring, Pharmacovigilance, and Quality Assurance teams to ensure seamless study execution and milestone achievement.
Monitoring Strategy & Systems Oversight
Lead development, maintenance, and execution of clinical monitoring strategies, including Clinical Monitoring Plans (CMP) and Study Monitoring Plans (SMP).
Ensure accurate and timely setup and use of clinical systems such as CTMS, EDC, ePRO/eDiary, TMF, IVRS/IWRS, and central monitoring dashboards.
Oversee User Acceptance Testing (UAT), system access management, and audit trail reviews as required.
Team Leadership & Quality Assurance
Oversee resourcing, assignments, and performance of CRAs and Central Monitors, ensuring delivery quality and compliance.
Review and approve monitoring documentation, including visit reports, monitoring calls, site letters, and central monitoring outputs.
Drive inspection readiness activities and support audits and regulatory inspections.
Coach and mentor Clinical Trial Managers (CTMs) and monitoring staff, providing input on performance, development, and corrective action planning.
Required Qualifications & Experience
Education
Bachelor’s degree in Life Sciences, Nursing, Pharmacy, or a related discipline, or
Registered Nurse (RN) qualification, or
Equivalent combination of education, training, and professional experience.
Professional Experience
Minimum 7–10 years of experience in clinical research, with significant experience in clinical trial management and site monitoring.
Proven leadership experience managing global or regional early-phase (Phase I–II) clinical trials.
Demonstrated expertise in site management, clinical monitoring, and central monitoring activities.
Experience with risk-based monitoring methodologies preferred.
Strong understanding of clinical trial financial principles, including budget oversight and cost control.
Experience working in a global, sponsor-dedicated or CRO environment.
Skills & Competencies
In-depth knowledge of ICH-GCP, regulatory requirements, and clinical trial operational standards.
Strong project leadership, team alignment, and stakeholder management skills.
Excellent problem-solving, risk assessment, and decision-making capabilities.
Strong conflict resolution and communication skills, with the ability to operate effectively in complex global environments.
High proficiency with clinical trial systems and reporting tools.
Ability to travel moderately, approximately 20%, as required.
Why Join Syneos Health
Work in a sponsor-dedicated, globally visible leadership role within early clinical development.
Collaborate on innovative programs supporting the majority of FDA-approved and EMA-authorized products.
Benefit from structured career development, technical training, and leadership growth opportunities.
Be part of an inclusive, people-focused organization committed to professional excellence and well-being.
Additional Information
This job description reflects the core responsibilities of the role but is not exhaustive. Syneos Health reserves the right to modify duties and requirements in line with business needs. The company is an equal opportunity employer and complies with all applicable employment and accessibility regulations.
SEO & AI Optimization Keywords
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