Clinical Trial Manager - Sponsor Dedicated (Remote, With Travel))

Syneos Health

6-10 years

preferred by company

10 Feb. 6, 2026

Job Description

Job Type: Full Time Education: B.Sc./ M.Sc./ M.Pharm/ B.Pharm/ Life Sciences Skills: Causality Assessment, Clinical SAS Programming, Communication Skills, CPC Certified, GCP guidelines, ICD-10 CM Codes, CPT-Codes, HCPCS Codes, ICD-10 CM, CPT, HCPCS Coding, ICH guidelines, ICSR Case Processing, Interpersonal Skill, Labelling Assessment, MedDRA Coding, Medical Billing, Medical Coding, Medical Terminology, Narrative Writing, Research & Development, Technical Skill, Triage of ICSRs, WHO DD Coding

Clinical Trial Manager – Sponsor Dedicated (Remote with Travel)

Updated: February 3, 2026
Location: London, England, United Kingdom
Work Mode: Remote with Moderate Travel
Job ID: 25105121
Company: Syneos Health®

Job Overview

Syneos Health®, a globally integrated biopharmaceutical solutions organization, is seeking an experienced Clinical Trial Manager (CTM) for a Sponsor-Dedicated engagement. This role is responsible for end-to-end oversight of clinical trial execution, with a strong focus on patient safety, regulatory compliance, data integrity, and delivery of study milestones.

The position operates remotely with approximately 20% travel and requires close collaboration with sponsors, investigator sites, and cross-functional clinical teams across global studies.

Key Responsibilities

Provide overall oversight of site management, clinical monitoring, and central monitoring activities in alignment with protocol, ICH-GCP, regulatory requirements, and sponsor expectations.
Manage site activities from post-activation through site closeout, including patient recruitment, investigator payments, and site performance oversight.
Identify critical data, process risks, and protocol execution risks through completion and maintenance of the Risk Assessment and Categorization Tool (RACT).
Review study scope of work, budget, and protocol to ensure clinical teams understand contractual obligations and deliverables.
Analyze operational metrics, monitoring reports, and study data to proactively identify risks to timelines, quality, and budget.
Escalate project risks, out-of-scope activities, and operational challenges to project management and sponsor stakeholders.
Apply strategic problem-solving and risk mitigation approaches to ensure successful study delivery.
Participate in and present at key study meetings, including Kick-Off Meetings and governance forums.
Serve as an escalation point for investigator site communications and support conflict resolution when required.
Collaborate with Study Start-Up, Data Management, Patient Recruitment, Pharmacovigilance, and Quality Assurance teams to achieve site activation, enrollment, and database lock milestones.
Develop, maintain, and oversee clinical trial tools and documentation, including the Clinical Monitoring Plan (CMP).
Ensure proper setup, validation, and use of clinical systems such as CTMS, EDC, ePRO/eDiary, TMF, IVRS/IWRS, and monitoring dashboards.
Coordinate and deliver protocol-specific and operational training to CRAs, Central Monitors, and study team members.
Oversee CRA and Central Monitor resourcing, performance, training compliance, and study conduct.
Review and approve site monitoring reports, central monitoring documentation, correspondence, and risk communications within CTMS.
Provide regular status updates to sponsors and internal leadership on clinical trial progress, risks, and mitigation strategies.
Support inspection readiness and regulatory audits related to clinical trial management activities.
Provide performance feedback to line managers and contribute to staff development initiatives.
Support data cut and database lock activities in alignment with study timelines.
Manage larger or more complex trials as assigned.

Required Qualifications and Experience

Education: Bachelor’s degree in Life Sciences, Nursing (RN), or a related field, or an equivalent combination of education and experience.
Experience:
- Minimum 6–10 years of clinical research experience, with significant experience in clinical trial management or site monitoring.
- Proven experience overseeing global or regional clinical trials within a CRO or sponsor environment.
Demonstrated expertise in site management, clinical monitoring, and central monitoring.
Strong understanding of ICH-GCP, global regulatory requirements, and clinical trial operations.
Experience with risk-based monitoring methodologies is preferred.
Solid understanding of clinical trial budgets, financial tracking, and resource planning.
Proficiency with clinical trial systems including CTMS, EDC, TMF, and monitoring dashboards.
Excellent communication, presentation, and stakeholder management skills.
Strong conflict resolution, critical thinking, and problem-solving abilities.
Ability to work effectively in a global, matrixed environment.
Willingness to travel moderately (approximately 20%).

Why Join Syneos Health?

Syneos Health partners with customers to accelerate the delivery of life-changing therapies worldwide. Over the past five years, the organization has supported 94% of novel FDA-approved drugs and 95% of EMA-authorized products, managing more than 200 clinical studies across 73,000 sites and 675,000+ trial participants.

Employees benefit from:

Structured career development and progression pathways
Technical and therapeutic area training
Supportive leadership and performance recognition programs
A diverse, inclusive, and globally connected workplace
Opportunities to work on complex, high-impact clinical research programs

Additional Information

This job description is not intended to be exhaustive. Syneos Health reserves the right to assign additional responsibilities as business needs evolve. Equivalent education, experience, and skills may be considered. The company is committed to equal employment opportunity and compliance with applicable employment and disability legislation.

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Clinical Trial Manager - Sponsor Dedicated (Remote, With Travel))

Job Description

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