Clinical Trial Manager II – Study Manager (Real World Evidence & Contract Negotiation)
Updated: February 3, 2026
Location: London, United Kingdom
Job ID: 25105454-OTHLOC-3526-2DR
Employment Type: Full-time / Contract-based (as applicable)
About Syneos Health
Syneos Health® is a globally integrated biopharmaceutical solutions organization dedicated to accelerating clinical, medical, and commercial success. With a patient-centric Clinical Development model, Syneos Health partners with life sciences organizations to deliver high-quality outcomes across clinical trials, real-world evidence (RWE), and regulatory pathways. Operating across more than 110 countries with over 29,000 professionals, Syneos Health is committed to innovation, operational excellence, and inclusive global collaboration.
Position Overview
The Clinical Trial Manager II – Study Manager (RWE) is responsible for the end-to-end operational delivery of multiple global real-world evidence and clinical studies. This role plays a critical leadership function in study execution, vendor oversight, contract negotiation, and budget management, while ensuring compliance with GCP, regulatory standards, and quality frameworks. The position requires strong project management capability, contract facilitation expertise, and cross-functional collaboration skills.
Key Responsibilities
Study & Operational Management
Lead the operational execution of 10–12 concurrent RWE and clinical studies, ensuring on-time, high-quality delivery across global regions.
Support feasibility assessments, site engagement strategies, and study start-up activities using global operational expertise.
Apply clinical research experience, including monitoring knowledge, to assess site performance and proactively identify operational risks.
Contract & Budget Oversight
Manage contract facilitation and negotiation processes by gathering operational requirements, identifying contractual risks, and aligning stakeholder expectations.
Lead study budget development, including Fair Market Value (FMV) assessments, cost projections, milestone planning, and financial forecasting.
Maintain financial oversight to ensure cost control, accuracy, and proactive risk mitigation.
Vendor & Stakeholder Collaboration
Serve as the primary operational contact for external research partners, CROs, and vendors.
Oversee vendor performance to ensure alignment on deliverables, timelines, data flow, and study quality standards.
Collaborate closely with cross-functional teams including Clinical Operations, Data Management, Regulatory Affairs, Medical Affairs, and Procurement.
Risk, Quality & Compliance
Monitor operational risks across all assigned studies and implement mitigation strategies as required.
Support inspection readiness, audits, and regulatory compliance activities across global studies.
Ensure adherence to GCP, SOPs, and applicable regional and international regulations.
Communication & Continuous Improvement
Communicate proactively with internal and external stakeholders to maintain transparency on timelines, expectations, and study progress.
Apply analytical and strategic thinking to interpret study-level data and drive continuous improvement in operational processes.
Required Qualifications & Experience
Education
Bachelor’s degree in Life Sciences, Nursing, Pharmacy, or a related discipline with a minimum of 2 years of relevant experience, OR
Master’s degree or PhD in a scientific or clinical discipline with at least 1 year of relevant experience.
Professional Experience
Proven experience in clinical trial or study management, with a strong understanding of GCP, monitoring, and clinical/regulatory operations.
Real World Evidence (RWE) experience strongly preferred.
Demonstrated experience managing CROs, vendors, and external research partners.
Hands-on experience with contract negotiation and contract facilitation, including requirements gathering and risk identification.
Strong background in budget management, FMV analysis, cost metrics, and milestone planning.
Skills & Competencies
Excellent project management, organizational, and prioritization skills.
Strong analytical and problem-solving capabilities with the ability to interpret operational and study-level data.
Effective cross-functional collaboration and stakeholder management skills.
High level of attention to detail and proficiency with operational tools, metrics, and reporting systems.
Excellent written and verbal communication skills with fluency in English and cross-cultural awareness.
Why Join Syneos Health
Exposure to global, high-impact clinical and RWE programs.
Career development through structured training, mentorship, and progression pathways.
Inclusive, people-first culture focused on well-being, diversity, and professional growth.
Opportunity to contribute to studies supporting the majority of recent FDA-approved and EMA-authorized therapies.
Additional Information
This job description outlines the primary responsibilities and qualifications for the role; however, duties may evolve based on business needs. Syneos Health is an equal opportunity employer and complies with all applicable employment legislation, including reasonable accommodations where required.
Keywords for AI & Search Optimization
Clinical Trial Manager II, Study Manager RWE, Real World Evidence Jobs UK, Clinical Operations Manager London, Contract Negotiation Clinical Trials, Global Clinical Research Jobs, CRO Management Roles, Syneos Health Careers, Pharma Clinical Project Management
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