Job Title:
Scientific Director – Medicinal Chemistry – Oral Macrocyclic Peptides
Location:
Indianapolis, Indiana, United States
Job ID: R-69197
Category: Research & Development
Job Type: Full-Time, Regular
Company Overview:
Eli Lilly is a global pharmaceutical leader dedicated to discovering and delivering medicines that improve lives. The organization values people-first innovation, diversity, and excellence in science.
Role Summary:
This is a technical leadership role within the Peptide Therapeutics Team in Biotechnology Discovery Research. The Director will lead the medicinal chemistry strategy for oral macrocyclic peptides, focusing on target-to-clinic development, and guide a multidisciplinary team toward delivering novel peptide-based therapeutics.
Key Responsibilities:
Leadership & Strategic Direction
Lead a team in the design, optimization, and advancement of oral macrocyclic peptides.
Initiate and manage new discovery projects in macrocyclic peptides, including library screening and SAR strategy.
Provide vision, technical leadership, and mentorship across therapeutic projects.
Scientific & Technical Excellence
Utilize peptide chemistry, conformational analysis, modeling, and computational design to enhance oral bioavailability and pharmacokinetics.
Develop and apply strategies for hit identification and lead optimization using tools such as:
OBOC
AS/MS
mRNA display
Solution-phase screening
Cross-Functional Collaboration
Work across Lilly’s discovery and development functions (DCRT, TA Teams, Drug Disposition, Product Development, Regulatory).
Communicate progress to management and governance committees.
Team Development & Inclusion
Promote a culture of innovation, safety, inclusion, and diversity.
Recruit, coach, and develop scientific talent and future leaders.
Basic Qualifications:
PhD or postdoctoral degree in synthetic chemistry, peptide chemistry, or related field.
5+ years of experience in pharmaceutical/biotech R&D.
Preferred Qualifications:
Deep expertise in oral macrocyclic peptide design, development, and screening.
Experience with both computational approaches and wet-lab execution.
Track record of leading successful drug development efforts from discovery through clinical testing.
Understanding of AI/ML in macrocycle drug discovery is a strong plus.
Ability to influence and lead within a matrixed global R&D organization.
Compensation & Benefits:
Anticipated Salary: $139,500 – $246,400
Eligible for bonus compensation based on performance.
Full benefits package includes:
401(k), pension
Health, dental, vision
Paid vacation and time off
Wellness and life insurance benefits
Diversity & Inclusion:
Lilly is an EEO employer committed to equal opportunity and diversity in the workforce. The company actively supports employee resource groups (ERGs), including WILL, PRIDE, VLN, enAble, OLA, and others.
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