Advisor / Senior Advisor – Bioconjugation Process Development
Location: Indianapolis, Indiana, USA
Category: Research & Development
Job Type: Full-Time, Regular
Job ID: R-95989
Company Overview:
Lilly is a global healthcare leader headquartered in Indianapolis, Indiana, dedicated to discovering and delivering life-changing medicines worldwide. Our mission combines innovative research with patient-focused care, advancing disease understanding, improving health outcomes, and supporting communities through philanthropy and volunteerism. At Lilly, we prioritize people, innovation, and scientific excellence to make life better globally.
Organization Overview:
Bioproduct Research and Development (BRD) at Lilly focuses on large-molecule process development for biologic therapeutics, including monoclonal antibodies (mAbs) and bioconjugates. BRD drives material and data generation to support clinical trials and commercialization. The team works at the forefront of antibody-drug conjugates (ADCs), antibody-peptide conjugates (APCs), and antibody-RNA conjugates (ARCs/AOCs), collaborating closely with discovery, synthetic molecule design, and biologics development teams to accelerate innovative therapeutics for patients.
Position Summary:
Lilly is seeking an experienced Advisor / Senior Advisor in Bioconjugation Process Development to join our dynamic team. The ideal candidate will have expertise in synthetic organic chemistry and bioconjugation, contributing to the development of innovative processes for next-generation therapeutics. This role combines hands-on research, leadership, and cross-disciplinary collaboration to enhance our bioconjugation platform, supporting both clinical development and commercial manufacturing.
Key Responsibilities:
Lead and conduct experimental research on bioconjugation processes, including ADCs, APCs, and ARCs, ensuring high-quality data generation and reproducibility.
Design, execute, and optimize process development strategies, proposing new methods and analytical approaches to improve bioconjugate synthesis.
Collaborate across discovery, synthetic molecule, and biologics development teams to translate research insights into actionable development plans.
Analyze results, draw conclusions, and communicate findings effectively to internal teams and external stakeholders.
Contribute to the growth of research infrastructure, including laboratory setup, process equipment, and analytical capabilities.
Support commercial manufacturing strategies by developing robust, scalable processes for large-scale production.
Engage with the scientific community through conferences, publications, and external collaborations to incorporate innovative methodologies and maintain a competitive edge.
Demonstrate flexibility and adaptability, navigating multiple scientific challenges across modalities (small molecules, peptides, oligonucleotides) while managing ambiguity.
Qualifications:
PhD in Synthetic Organic Chemistry, Biochemistry, Chemical Biology, or a related field or MS with 5+ years of relevant industrial experience.
Postdoctoral experience in bioconjugation is highly preferred.
Hands-on expertise in small molecule synthesis, reaction mechanisms, and bioconjugation reactions at small scale.
Knowledge of antibody structure, class, and function.
Experience with analytical techniques such as RP-HPLC, SEC, IEX, HIC, LC-MS, and CE-SDS.
Experience handling highly potent small molecules safely.
Demonstrated track record of scientific collaboration, leadership, and self-initiative.
Strong communication, organizational, and problem-solving skills, with the ability to prioritize and manage multiple projects.
Experience with preparative-scale ADC or ARC purifications (TFF, IEX, etc.) is desirable.
Active engagement in scientific publications and external presentations.
Additional Information:
Exposure to chemicals, allergens, and laboratory environments; occasional travel (0–10%).
Full-time position based at Lilly Technology Center – North, Indianapolis, Indiana.
Compensation range: $126,000 – $204,600 per year, dependent on education, experience, and location.
Eligible for company bonus and comprehensive benefits including 401(k), pension, medical, dental, vision, life insurance, paid time off, flexible spending accounts, and wellness programs.
Diversity & Inclusion:
Lilly is an Equal Opportunity Employer committed to building a diverse and inclusive workforce. Individuals with disabilities are encouraged to request accommodations during the application process.
Apply Today:
Join Lilly’s Bioconjugation Process Development team and contribute to groundbreaking therapies that improve patient outcomes worldwide.
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