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    Scientific Director – Medicinal Chemistry, Oral Macrocyclic Peptides

    Eli Lily
    5+ years
    Not Disclosed
    Indianapolis
    10 Jan. 30, 2025
    Job Description
    Job Type: Full Time Education: B.Sc, M.Sc, B.Pharm, M.Pharm, LifeScience Graduates Skills: Causality Assessment, Clinical SAS Programming, Communication Skills, CPC Certified, GCP guidelines, ICD-10 CM Codes, CPT-Codes, HCPCS Codes, ICD-10 CM, CPT, HCPCS Coding, ICH guidelines, ICSR Case Processing, Interpersonal Skill, Labelling Assessment, MedDRA Coding, Medical Billing, Medical Coding, Medical Terminology, Narrative Writing, Research & Development, Technical Skill, Triage of ICSRs, WHO DD Coding

    Job Title: Scientific Director – Medicinal Chemistry, Oral Macrocyclic Peptides
    Location: Indianapolis, Indiana, United States
    Category: Research & Development
    Job Type: Full-Time, Regular
    Job ID: R-69197

    About Eli Lilly

    Eli Lilly and Company is a global healthcare leader committed to improving the lives of people around the world. Based in Indianapolis, Indiana, our employees work tirelessly to develop life-changing medicines, advance the understanding of diseases, and contribute to communities through philanthropy and volunteer efforts. We believe in scientific innovation and are dedicated to making the world a better place through our research.

    Position Overview

    We are seeking a Scientific Director – Medicinal Chemistry with a focus on Oral Macrocyclic Peptides to join our Peptide Therapeutics Team within the Biotechnology Discovery Research division in Indianapolis. The ideal candidate will have a proven track record in leading drug discovery efforts, particularly in oral macrocyclic peptides, and driving scientific strategies to move novel therapeutics from the discovery phase through clinical development. This role involves leading a multidisciplinary team, developing strategies, and overseeing the execution of research efforts to advance oral peptide therapeutics.

    Key Responsibilities

    • Leadership: Lead the Medicinal Chemistry Group in advancing research on oral macrocyclic peptides, from target identification to lead optimization. Manage and mentor scientists within the team and collaborate with cross-functional stakeholders.
    • Strategic Planning: Formulate, implement, and execute strategies for the advancement of peptide research projects, ensuring timely progress from discovery through candidate declaration.
    • Scientific Expertise: Apply knowledge of peptide synthesis, conformational analysis, molecular modeling, and computational methods to optimize lead candidates. Utilize SAR strategies to enhance pharmaceutical properties of peptides.
    • Cross-functional Collaboration: Work closely with Discovery Chemistry, Therapeutic Area Teams, Drug Disposition, Product Development, and Regulatory Affairs to drive successful therapeutic development.
    • Innovation: Stay at the forefront of new developments in peptide therapeutics, implementing fresh ideas and solutions to overcome challenges related to peptide engineering, drug development, and biological activity.
    • Team Development: Foster a collaborative, high-performance culture within the team. Provide mentorship and coaching to scientists, promote diversity and inclusion, and encourage innovative thinking and the generation of high-quality scientific hypotheses.

    Qualifications

    Basic Requirements:

    • PhD or postdoctoral degree in Chemistry, Synthetic Chemistry, Peptide Chemistry, or a related field with a focus on drug discovery and development.
    • A minimum of 5 years of experience in a biotechnology or pharmaceutical company, specifically in peptide therapeutics and drug discovery.

    Preferred Qualifications:

    • Expertise in oral macrocyclic peptides, including familiarity with library-based screening technologies (e.g., OBOC, solution-phase, AS/MS, mRNA display).
    • Proven leadership in developing novel medicines, with a strong understanding of computational and structural methods for hit identification and lead optimization.
    • Successful track record of advancing drug candidates from concept to clinical development.
    • Experience with AI/machine learning techniques for peptide development and optimization.
    • Ability to lead cross-functional teams and collaborate with senior leadership within a matrixed global organization.
    • Strong problem-solving abilities, attention to detail, and the capacity to lead high-performing teams.

    Skills and Competencies:

    • Excellent communication and presentation skills, with the ability to effectively communicate complex scientific information to diverse stakeholders.
    • Strong interpersonal skills and the ability to inspire collaboration and build productive working relationships across teams and functions.
    • A commitment to safety and the promotion of a safety-first culture.
    • A passion for fostering diversity and inclusion within the team and organization, with a focus on mentoring and developing talent.

    Equal Opportunity Employer

    Eli Lilly is an Equal Opportunity Employer and does not discriminate based on race, color, religion, gender, sexual orientation, gender identity, national origin, disability, veteran status, or any other legally protected status. We are committed to helping individuals with disabilities participate in the workforce and ensuring equal opportunities in the hiring process. If you need assistance submitting your resume or have any specific accommodations, please reach out to Lilly_Recruiting_Compliance@lists.lilly.com.

    Benefits

    At Lilly, we offer a comprehensive benefits package that includes competitive salaries, health insurance, retirement plans, paid time off, and well-being programs. We also support employee development through leadership programs, mentorship, and internal growth opportunities.

    #WeAreLilly 

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