Position Title: Advisor – Computational Biology
Job ID: R-93313
Category: Research & Development
Job Type: Full Time, Regular
Location: Boston, Massachusetts, USA
🌍 About Lilly
Lilly unites caring with discovery to improve global healthcare. Employees:
Develop and deliver life-changing medicines
Advance understanding and management of disease
Contribute to communities via philanthropy and volunteerism
The Gene Therapy team at Lilly focuses on inventing, characterizing, and advancing novel genome therapy reagents across multiple disease areas and platforms to deliver on the promise of gene therapy for patients worldwide.
🎯 Role Purpose
The Advisor – Computational Biology supports Lilly Gene Therapy Discovery and Platform Research (GTDPR) by:
Analyzing complex genomic datasets to support AAV vector development, capsid engineering, payload engineering, and biodistribution studies
Collaborating with cross-functional teams including molecular biology, vector engineering, and pre-clinical development
Advancing innovative gene therapies from discovery through IND-enabling studies
Reports to: Executive Director – Vector Engineering and Delivery
🧠 Key Responsibilities
Bioinformatics Pipeline Development: Design, execute, and maintain pipelines for bulk/single-cell RNA-seq, AAV integration, vector genome sequencing, and capsid library screening
NGS Data Analysis: End-to-end analysis including quality control, variant calling, differential expression, and biological interpretation
AAV Vector Characterization: Computational methods for integration site analysis, biodistribution assessment, and tissue-/disease-specific interpretation
Capsid Engineering Support: Structure-function analysis and receptor binding predictions
Transcriptomic/Proteomic Analysis: Identify therapeutic targets and biomarkers for gene therapy applications
Cross-Functional Collaboration: Work closely with Lilly Gene Therapy and broader Lilly Research Laboratories teams to meet project milestones
Data Communication: Present findings to internal teams and stakeholders
🎓 Basic Requirements
PhD in Bioinformatics, Computational Biology, Genomics, or related scientific field
Minimum 2 years industry experience in NGS data analysis and/or structural modeling
🛠 Additional Preferences
Publication record in computational biology or bioinformatics methods
Familiarity with AAV biology, capsid engineering, and gene therapy applications
Strong written/verbal communication skills
Experience with project management and handling multiple projects
Experience in multidisciplinary, collaborative research environments
Attention to detail and commitment to reproducible research practices
Background in structural biology and protein engineering
Experience with machine learning applications in biotech and drug discovery
✈️ Travel
Up to 10–15% travel for conferences or training
💰 Compensation & Benefits
Salary Range: $156,750 – $250,800
Eligible for company bonus
Benefits include: 401(k), pension, vacation, medical, dental, vision, flexible spending accounts, life insurance, wellness programs, and more
🔖 #WeAreLilly
Equal Opportunity Employer
Workplace accommodations available for individuals with disabilities
Employee Resource Groups (ERGs) support inclusion and networking, e.g., PRIDE, WILL, VLN, enAble, and others
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