Senior Scientist II, DMPK
Location: Alameda, California, USA | Full-Time | Onsite
Position Summary
The Senior Scientist II, DMPK plays a critical role in advancing Exelixis’ drug discovery programs by providing strategic scientific leadership in ADME, pharmacokinetics, and PK/PD modeling. This position works closely with multidisciplinary teams to design, execute, and interpret in vitro and in vivo DMPK studies that support human dose prediction and overall project progression. The role requires strong expertise in drug metabolism, quantitative pharmacology, modeling and simulation, and collaborative scientific problem-solving to drive discovery programs toward key milestones.
Key Responsibilities
Serve as the DMPK subject matter expert on discovery project teams, collaborating to evaluate compound properties and support candidate selection.
Design, analyze, and interpret PK, toxicology, and pharmacology studies to guide project decision-making.
Lead Modeling and Simulation activities to understand exposure–response relationships and predict pharmacodynamic, efficacy, toxicity, and drug interaction risks.
Partner with Discovery and Development leadership to evolve and implement PK/PD and PBPK strategies across pipeline programs.
Collaborate closely with Clinical Pharmacology to enable smooth transition into development and support interactions with regulatory agencies.
Contribute to scientific visibility through publications, presentations, and strategic external engagement.
Provide scientific guidance to internal and external collaborators, including CROs.
Present findings to senior leadership, cross-functional project teams, and external partners.
Foster a high-performance culture emphasizing scientific excellence, innovation, accountability, and collaboration.
Adhere to all laboratory safety policies and company health standards.
Supervisory Responsibilities
May provide leadership and management to scientists within Drug Discovery Sciences.
Required Education and Experience
Education Requirements:
Bachelor’s degree in Pharmacokinetics, Drug Metabolism, Pharmaceutical Sciences, Chemical Engineering, or a related field with minimum 9 years of experience; or
Master’s degree in relevant discipline with minimum 7 years of experience; or
PhD in a relevant field with minimum 2 years of experience; or
Equivalent combination of education and experience.
Experience Requirements:
Relevant biopharmaceutical industry experience with strong understanding of ADME principles.
Extensive experience in designing, conducting, and interpreting in vitro and in vivo ADME studies.
Direct experience applying DMPK strategies in small-molecule oncology drug discovery.
Proven ability to lead DMPK strategy across multidisciplinary discovery teams.
Hands-on experience with Modeling and Simulation to evaluate PK/PD, efficacy, toxicity, and drug interaction risks.
Experience managing CRO partnerships is preferred.
Familiarity with regulatory expectations and prior regulatory interactions is an advantage.
Skills and Competencies
Strong scientific expertise in drug metabolism, enzymology, enzyme kinetics, and ADME sciences.
Ability to investigate complex DMPK challenges using data-driven approaches.
Solid understanding of PK/PD and quantitative pharmacology concepts.
Proficiency with PK/PD and PBPK software (e.g., Phoenix WinNonlin, GastroPlus).
Demonstrated leadership, scientific influence, and effective decision-making.
Excellent written, verbal, and presentation communication skills.
Strong ability to manage multiple priorities and work independently.
Effective collaboration with multidisciplinary internal teams and external partners.
Working Conditions
Onsite role based in Alameda, California.
Travel requirements: Less than 10%, including visits to CROs and relevant scientific meetings.
Compensation and Benefits
Compensation is aligned with U.S. geographic labor markets.
Base Pay Range: USD 128,500 – 181,500 annually.
Final compensation depends on geographic location, experience, skills, and internal equity.
Total Rewards Package Includes:
Comprehensive medical, dental, and vision insurance
401(k) plan with company contributions
Life and disability insurance
Flexible spending accounts
Annual discretionary bonus or sales incentive plan
Employee stock purchase program and long-term incentive opportunities
15 vacation days in the first year
17 paid holidays, including a company-wide winter shutdown
Up to 10 sick days annually
Disclaimer
This job description outlines the general nature and responsibilities of the role. It is not intended to be an exhaustive list of all duties, qualifications, or expectations associated with the position.
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