Senior Principal Pharmacometrician | Cambridge, MA / East Hanover, NJ (Hybrid)
Job Summary:
Novartis is seeking a Senior Principal Pharmacometrician to lead global pharmacometric strategy and modeling in support of clinical development. This role is vital for applying model-informed drug development (MIDD) strategies and contributing to regulatory submissions, dose optimization, and clinical trial design. Based in Cambridge, MA or East Hanover, NJ, this is a hybrid position (3 days/week onsite) offering a competitive salary between $119,700 and $222,300 per year.
Key Responsibilities:
Lead global pharmacometric support for clinical programs of low to mid complexity
Apply PK/PD modeling, disease progression modeling, and simulation techniques
Translate biological and clinical data into actionable insights for development strategy
Develop regulatory submission strategies including summaries and responses
Integrate Real World Data into pharmacometric analyses for evidence generation
Collaborate cross-functionally with statisticians, data managers, and medical writers
Communicate modeling outcomes and implications to internal and external stakeholders
Required Skills & Qualifications:
Ph.D. in pharmacology, biology, engineering, mathematics, or statistics
Minimum 3+ years of experience in clinical drug development with PK/PD modeling
Expertise in NLME modeling, dose-exposure-response analysis, and trial simulations
Experience applying MIDD strategies in various therapeutic areas
Strong communication skills for cross-functional collaboration and regulatory interactions
Perks & Benefits:
Competitive salary: $119,700 – $222,300 per year
Performance-based cash incentive and annual equity award eligibility
Comprehensive health, life, and disability insurance
401(k) with company match and contribution
Generous paid time off including vacation, sick leave, holidays, and parental leave
Access to training and professional growth opportunities
Company Description:
Novartis is a global healthcare leader focused on reimagining medicine to improve patient lives. With a strong foundation in scientific innovation, clinical development, and regulatory excellence, Novartis fosters a collaborative culture to solve some of the most pressing challenges in modern healthcare.
Work Mode:
Hybrid – 3 days per week onsite in Cambridge, MA or East Hanover, NJ
Call to Action:
Ready to shape the future of clinical pharmacology and pharmacometrics? Apply now to join Novartis and make a global impact through evidence-based drug development.
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