Job Title: Scientist – Small Molecule Technology
Company: Pfizer
Location: India – Chennai (On Premise)
Employment Type: Full-Time
Job ID: 4951565
Experience Required: Minimum 5–7 years of experience in small molecule process development, synthetic chemistry, or API manufacturing.
About Pfizer
Pfizer is a global biopharmaceutical leader committed to delivering breakthroughs that improve patient lives. Our Research & Development and Global Supply teams focus on developing safe, robust, and scalable processes for pharmaceuticals, ensuring the highest quality standards from lab to commercial production.
Role Summary
The Scientist – Small Molecule Technology is responsible for the development of efficient, scalable, and safe processes for intermediates and Active Pharmaceutical Ingredients (APIs). This role involves process design, optimization, scale-up, and collaboration across multi-disciplinary teams to support Pfizer’s manufacturing and supply chain operations.
Key Responsibilities
Process Development & Optimization
Develop robust and scalable synthetic processes for intermediates and APIs suitable for pilot plant and commercial production.
Conduct literature reviews and identify alternative synthetic routes for process development.
Perform lab feasibility studies, process optimization, pre-validation, Critical Process Parameters (CPP) studies, and validation experiments.
Plan and execute stress studies, holding time studies, mass balance, recovery, and scale-up studies.
Analyze experimental data, interpret results, and provide scientific rationale for process decisions.
Apply novel experimental approaches, investigating innovative methodologies to improve efficiency and safety.
Collaboration & Cross-Functional Engagement
Partner with Process Engineers, Analytical Chemists, Process Safety teams, Crystallization Technologists, and pilot plant colleagues across Pfizer global sites.
Support production teams in scale-up and troubleshooting of process challenges.
Coordinate with regulatory, quality, and instrumentation teams for compliance and instrument qualification.
Participate in project discussions, brainstorming sessions, and process improvement initiatives.
Documentation & Compliance
Prepare technical reports, experimental records, and project updates to support management decisions.
Ensure adherence to cGMP, GSP procedures, and internal compliance standards.
Maintain accurate records in electronic lab notebooks (Biovia eLN, GDMS, LIMS, etc.) and other documentation systems.
Apply ICH guidelines and safety principles in all laboratory activities.
Qualifications & Experience
Ph.D. in Organic Chemistry or a related field.
Strong experience in synthetic chemistry, reaction development, characterization (NMR, IR, Mass Spectrometry), chromatography, and crystallization techniques.
Demonstrated ability to design experiments, interpret data, and provide scientific recommendations.
Experience in cross-functional and matrixed teams, with strong collaboration and stakeholder engagement skills.
Proficiency in preparing scientific reports, project documentation, and compliance adherence.
Knowledge of process safety, quality principles, and laboratory instrumentation.
Why Join Pfizer?
This role offers an opportunity to contribute to high-impact projects in small molecule process development while collaborating with global teams. You will play a key role in ensuring efficient, safe, and scalable production of critical pharmaceutical ingredients, directly impacting patient access to life-saving medicines.
Work Location: On Premise – Chennai, India
Pfizer is an equal opportunity employer and adheres to all applicable employment legislation in each jurisdiction.
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