Scientist – Small Molecule Technology
Location: Chennai, India
Employment Type: Full-Time | On-site
Job Requisition ID: 4949905
Functional Area: Research & Development | Small Molecule Process Development | API Manufacturing
About the Role
Pfizer is seeking a Scientist – Small Molecule Technology to support the development, optimization, and scale-up of small molecule active pharmaceutical ingredients (APIs) and intermediates. This role plays a critical part in process development, technology transfer, impurity characterization, and manufacturing scale-up, ensuring robust, cost-effective, and compliant chemical processes.
The position requires strong expertise in synthetic organic chemistry, experimental design, and cGMP-compliant process development within a pharmaceutical R&D or manufacturing environment.
Key Responsibilities
Conduct comprehensive scientific literature reviews to identify and evaluate viable synthetic routes
Develop and optimize processes for APIs, intermediates, and raw starting materials (RSMs)
Drive yield improvement and cost reduction initiatives through process optimization
Plan and execute laboratory experiments aligned with process governance stages including feasibility, optimization, pre-validation, CPP, and validation
Design and execute Design of Experiments (DoE) to support process understanding and technology transfer
Analyze experimental data and recommend improvements related to quality, yield, safety, and scalability
Lead technology transfer activities to manufacturing plants and support MS&T and Kilo Lab (KGL) teams during scale-up
Investigate process challenges and propose scientifically sound solutions
Synthesize, isolate, and characterize process-related impurities
Prepare scientific reports, protocols, and technical documentation for manufacturing transfer
Ensure strict adherence to cGMP, safety standards, and Good Documentation Practices (GDP)
Support equipment installation, qualification, and laboratory readiness
Manage laboratory operations, inventory, safety compliance, and supervise junior team members
Contribute to innovation and continuous improvement projects within small molecule development
Experience Required
Ph.D. in Chemistry (Organic Chemistry or related discipline)
3–6 years of relevant experience in pharmaceutical R&D, process development, or manufacturing support
Postdoctoral experience may be considered equivalent to industry experience
Proven hands-on experience in small molecule synthesis, reaction optimization, and purification
Exposure to technology transfer and scale-up activities in a GMP environment
Required Skills & Competencies
Strong expertise in synthetic organic chemistry and analytical characterization of organic compounds
In-depth understanding of process development, impurity profiling, and scale-up principles
Knowledge of cGMP, safety regulations, and pharmaceutical quality systems
Ability to independently design experiments and solve complex technical challenges
Excellent written, verbal, and interpersonal communication skills
Demonstrated leadership capabilities and collaborative working style
Highly motivated, self-driven professional with strong problem-solving skills
Work Location
On-site – Chennai, India
Why Join Pfizer
Work on cutting-edge small molecule technologies impacting global patient care
Collaborate with world-class R&D and manufacturing teams
Gain exposure to end-to-end process development and commercial scale-up
Be part of a science-driven organization committed to quality, safety, and innovation
Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.
SEO & GPT Optimization Keywords
Scientist Small Molecule Jobs India, Pfizer R&D Scientist Chennai, API Process Development Scientist, Pharmaceutical Chemistry Jobs India, Small Molecule Technology Careers
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