Clinical Program Leader – Translational Clinical Oncology | Novartis | Cambridge, MA
Job Summary
Novartis is hiring a Clinical Program Leader (CPL) or Senior Clinical Program Leader (Senior CPL) for Translational Clinical Oncology (TCO) based on-site in Cambridge, MA. This high-impact role is responsible for strategy, planning, and execution of early-phase oncology trials, working across disciplines including pharmacology, biomarkers, and biostatistics. You will lead global programs in the development of innovative cancer therapies that impact patient lives.
Key Responsibilities
Provide strategic clinical guidance from development candidate phase through early clinical trials.
Design clinical development strategies integrating preclinical and translational science data.
Lead global Biomedical Research Program Teams (BPTs) across oncology indications.
Act as medical monitor and primary liaison with investigators, regulatory agencies, and KOLs.
Oversee protocol development, CRFs, analysis plans, and study reports for early phase trials.
Mentor less experienced CPLs and support scientific engagement and publication strategy.
Evaluate external opportunities for oncology-focused business development.
Ensure ethical, compliant, and high-quality execution of global clinical studies.
Required Skills & Qualifications
MD or DO degree required, board certification in oncology preferred.
Clinical Program Leader: 1–3 years of early phase oncology clinical development experience.
Senior CPL: 3–5+ years of oncology drug development leadership experience.
Proven ability to interpret preclinical data (molecular biology, PK, pharmacology, toxicology).
Experience designing and executing proof-of-concept (PoC) studies.
Strong understanding of GCP, regulatory standards, and global clinical operations.
Effective communicator with strong leadership, mentorship, and cross-functional collaboration skills.
Familiarity with PK/PD modeling and biostatistical principles in oncology trials.
Perks & Benefits
Salary Range:
CPL: $152,600 – $283,400/year
Senior CPL: $236,600 – $439,400/year
Performance-based compensation, sign-on bonus, RSUs, and discretionary awards
Comprehensive medical, dental, and vision coverage
401(k) with company contributions
Generous PTO, including sick leave, vacation, and parental leave
Professional growth and continuing education support
Company Description
Novartis Institutes for BioMedical Research (NIBR) is the innovation engine of Novartis. At NIBR, we harness cutting-edge translational science to accelerate the development of novel treatments in oncology and other critical disease areas. Our global research teams collaborate to deliver transformative therapies to patients worldwide.
Work Mode
On-site – Cambridge, Massachusetts
Travel: Up to 10% (domestic/international)
Call-to-Action
Are you a driven oncology leader ready to shape the future of cancer therapeutics? Join Novartis and help bring life-changing treatments to patients faster.
Apply now to be a part of translational innovation in oncology.
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