Associate Scientific Director – Translational Quantitative Pharmacology (TQP)
290678
Mumbai, Maharashtra, India
Full-time
At Merck, we unite curious minds across Healthcare, Life Science, and Electronics to push boundaries and create solutions that enrich human lives. Our purpose in Healthcare is to help create, improve, and prolong lives—especially in therapeutic areas such as Oncology, Neurology, and Fertility.
Joining Merck means joining a diverse, inclusive, and innovative global team with a passion for discovery and patient impact.
As the Associate Scientific Director, Translational Quantitative Pharmacology (TQP), you will contribute to Model Informed Drug Development (MIDD) strategies across the R&D lifecycle within the Quantitative Pharmacology (QP) team under the Clinical Measurement Sciences (CMS) organization. You will lead internal and outsourced TQP projects, develop mechanistic PK/PD models, and influence critical development decisions from discovery to early clinical phases.
Develop and implement mechanistic PK/PD models to inform compound progression decisions across immunology and oncology portfolios.
Execute human PK and drug-drug interaction (DDI) predictions.
Support First-in-Man (FIM) dose estimation for all drug modalities.
Design, analyze, and interpret preclinical PK/PD experiments and toxicological signals to determine therapeutic index.
Participate in development and application of modeling toolkits and strategies to support MIDD initiatives.
Oversee internal and outsourced TQP work.
Collaborate across disciplines such as:
Clinical Pharmacology
Biostatistics
Toxicology
DMPK
Biomarkers
Data Science
Represent QP in project teams, sub-teams, and internal committees.
Present modeling strategies and findings to cross-functional teams.
Contribute to regulatory documentation (e.g., IBs, INDs, CTDs).
Educate and mentor team members in modeling principles and applications.
Lead and participate in automation and AI-based model development for pharmacological and toxicological predictions.
Present research at scientific conferences and industry consortia.
Engage in academic partnerships and publish in peer-reviewed journals.
PhD in:
Pharmacokinetics
Pharmaceutical Sciences
Biomedical/Chemical Engineering
Applied Mathematics
Or a related discipline
Minimum 5 years of relevant experience in pharma/biotech or academia.
Proven expertise in:
Quantitative Systems Pharmacology (QSP)
Translational PK/PD modeling
Mechanism-based modeling
Toxicology modeling (e.g., DILI Sym, RenaSym)
Proficiency in modeling tools:
MATLAB/SimBiology
NONMEM
Monolix
R
Experience with:
PBPK modeling (e.g., Simcyp, GastroPlus)
Cardiovascular, hepatic, renal toxicity modeling
AI-based platforms (desirable)
Oncology, Neurology, Immunology Research Units
Clinical Pharmacology, Biostatistics, Safety Sciences, Biomarkers, DMPK
Project Teams and Functional Sub-teams
Academic research partners
Industry consortia (e.g., IQ Working Groups)
Contract Research Organizations (CROs)
Regulatory and scientific forums
Strong ability to translate complex biological mechanisms into multi-scale models
Clear communication of quantitative concepts to non-modeling stakeholders
Leadership in cross-functional environments
Publication track record in relevant scientific journals and conferences
Proactive, solution-driven, and adaptable to dynamic R&D environments
Competitive compensation and long-term financial benefits.
Physical and mental wellness programs, including health checkups and medical insurance.
Benefits for all stages of family life, including fertility support.
Generous leave policies for recharging and managing life events.
Access to flexible working, gyms, car benefits, and shopping discounts.
Apply: Submit your application online.
Screen: Applications are reviewed for role fit.
Assess: You may be interviewed via phone, video, or in-person.
Mutual Agreement: If aligned, an offer will be extended.
Onboard: Begin your journey with Merck with a structured onboarding experience.
Beware of unauthorized job offers. All legitimate roles are listed on Merck’s official career portal. Learn more about fraud prevention here.
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Berlin |Baden-Wurttemberg :
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Frankfurt | Harveysburg |Germany :
Germany | GErmany |Lower Saxony :
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Wuhan |Capital of Netherland :
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Queensland |Melbourne :
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England | Harlow | Leeds | London | Maidenhead | Salt Lake City | Stevenage | Stirling | United Kingdom |North Yorkshire :
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Zagreb |Estonia :
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