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Senior Scientist- Cell Line Development

2+ years
Preferred by Comapny
12 Nov. 24, 2024
Job Description
Job Type: Full Time Education: B.Sc./ M.Sc./ M.Pharm/ B.Pharm/ Life Sciences Skills: Causality Assessment, Clinical SAS Programming, Communication Skills, CPC Certified, GCP guidelines, ICD-10 CM Codes, CPT-Codes, HCPCS Codes, ICD-10 CM, CPT, HCPCS Coding, ICH guidelines, ICSR Case Processing, Interpersonal Skill, Labelling Assessment, MedDRA Coding, Medical Billing, Medical Coding, Medical Terminology, Narrative Writing, Research & Development, Technical Skill, Triage of ICSRs, WHO DD Coding

Job Title: Senior Scientist - Cell Line Development

Location: Ahmedabad, India
Company: Lambda Therapeutic Research Ltd.


About Lambda Therapeutic Research Ltd.

Lambda Therapeutic Research Ltd. is a premier Clinical Research Organization (CRO) with a global footprint, headquartered in Ahmedabad, India. With operations across India, the USA, Canada, UK, and Poland, Lambda specializes in providing end-to-end clinical research solutions to the pharmaceutical, biotech, and generic drug industries.

Known for excellence in regulatory compliance and innovation, Lambda has received numerous accolades, including the ‘Best Indian CRO’, the ‘Regulatory Excellence’ Award, and the ‘Industry Partner of the Year’ recognition.


Position Overview

The Senior Scientist - Cell Line Development will play a critical role in advancing cell line technologies to support the development of biologics and biosimilars. The position involves designing, executing, and optimizing workflows for stable cell line generation, process development, and analytical characterization.


Key Responsibilities

Cell Line Development

  • Design and execute strategies for the development of robust, high-yield, and stable cell lines for biologic production.
  • Lead efforts to engineer host cell lines using advanced techniques such as CRISPR, transfection, and cloning.
  • Develop processes for single-cell cloning, expansion, and screening to identify optimal clones.

Process Optimization

  • Optimize workflows for cell culture, media development, and scale-up processes.
  • Evaluate and implement cutting-edge technologies to enhance cell line productivity.
  • Troubleshoot and resolve challenges in cell line performance and stability.

Characterization and Analytics

  • Perform molecular and biochemical characterization of cell lines, including genetic stability and protein expression analysis.
  • Collaborate with analytical teams to ensure quality and regulatory compliance of cell lines.

Regulatory and Documentation

  • Prepare and maintain detailed protocols, reports, and regulatory documentation.
  • Ensure cell line development processes meet Good Laboratory Practices (GLP) and industry standards.

Collaboration and Leadership

  • Lead cross-functional teams to align cell line development efforts with project timelines and goals.
  • Mentor and train junior scientists and technicians in cell line development techniques.
  • Collaborate with upstream and downstream process development teams to ensure seamless integration of workflows.

Experience & Skills Required

Experience

  • 5+ years of experience in cell line development, with a focus on biologics or biosimilars production.
  • Hands-on expertise in mammalian cell culture, single-cell cloning, and genome editing technologies.

Educational Qualifications

  • Ph.D. in Biotechnology, Molecular Biology, Biochemistry, or a related field.
  • Candidates with a Master's degree and extensive relevant experience may also be considered.

Technical Skills

  • Proficiency in cell culture techniques, molecular biology methods, and high-throughput screening technologies.
  • Familiarity with analytical techniques such as qPCR, ELISA, SDS-PAGE, and flow cytometry.
  • Experience with bioreactor systems and scale-up processes is a plus.

Soft Skills

  • Strong problem-solving and troubleshooting abilities.
  • Excellent written and verbal communication skills for effective reporting and collaboration.
  • Ability to lead and mentor team members in a dynamic research environment.

Competencies

  • Technical Expertise: Advanced knowledge of cell line development techniques.
  • Innovation: Ability to integrate new technologies into existing workflows.
  • Leadership: Proven ability to lead projects and mentor teams.
  • Collaboration: Strong interpersonal skills to work across functional groups.
  • Accountability: Commitment to delivering high-quality results on time.

Why Join Lambda?

At Lambda, we are committed to fostering a culture of innovation, excellence, and teamwork. As a Senior Scientist - Cell Line Development, you will have the opportunity to contribute to groundbreaking projects in biologics and biosimilars development, shaping the future of therapeutic advancements.

Join Lambda Therapeutic Research Ltd. and be a part of a global team dedicated to redefining the landscape of healthcare and clinical research.