Project Toxicologist, Associate Director – Oncology Targeted Delivery Safety Science
Location: Waltham, Massachusetts, United States
(Also available at Boston Area, MA or Gaithersburg, MD Sites)
Job ID: R-239094
Date Posted: 09–10 Nov 2025
Closing Date: 23-Nov-2025
🔷 Role Introduction
AstraZeneca is driven by a bold ambition to eliminate cancer as a cause of death.
The Oncology Targeted Delivery (OTD) Safety team advances expert non-clinical safety science to support innovative oncology therapies.
The Associate Director, Project Toxicologist will contribute to the development of cutting-edge oncology medicines, including:
Radio Conjugates
Antibody Drug Conjugates (ADCs)
Small Molecules
You will bridge discovery, early development, and regulatory toxicology, ensuring safety strategies that support selection and progression of novel drug candidates.
🔷 Key Accountabilities
Toxicology & Safety Strategy
Design regulatory and investigative toxicology studies.
Predict, assess, and mitigate target- and modality-related safety risks.
Provide safety input for Radio Conjugates, ADCs, and small molecule programs.
Apply toxicology expertise to guide decisions in drug discovery & development.
Innovation & Scientific Integration
Drive integration of regulatory toxicology with advanced technologies (in vitro, in silico, in vivo).
Use modern tools such as organ-on-chip, imaging, and omics for mechanistic insights.
Support progression of drug candidates from discovery to clinic and beyond.
Regulatory & Governance Communication
Present integrated risk assessments to governance bodies.
Contribute to regulatory submissions, including IND-enabling toxicology packages.
Maintain expertise in global regulatory requirements and emerging safety science trends.
Cross-Functional & External Collaboration
Collaborate across Oncology R&D functions globally.
Provide non-clinical safety expertise for in-licensing evaluations.
Contribute to external collaborations, networks, and scientific publications.
🔷 Essential Skills & Experience
PhD and/or DABT in Toxicology, Pharmacology, Oncology, or related field.
3–5 years of experience as a Project Toxicologist / Investigative Toxicologist in pharma/biotech/CRO.
Strong understanding of:
Drug discovery and development
Non-clinical toxicology programs
IND-enabling studies
Expertise in Oncology, ideally with Radio Conjugates or ADC safety.
Experience using in vitro, in vivo, and in silico models for risk prediction.
Strong collaboration skills; ability to coordinate across multiple projects.
Ability to work independently and deliver toxicology risk assessments.
Excellent communication, presentation, and influencing skills.
Comfort working across geographies with an inclusive and diverse mindset.
🔷 Desirable Skills
(Not specified, considered as additional strengths)
🔷 Why AstraZeneca?
Work at the intersection of science and advanced analytics.
Influence high-impact deliverables across global therapy areas.
Culture of continuous learning, scientific curiosity, and innovation.
High-visibility role offering growth across diverse R&D functions.
Commitment to putting patients first while driving breakthrough oncology solutions.
🔷 Compensation & Benefits
Base Salary Range: $134,000 – $201,000 (USD annual).
Final offer depends on experience, skills, and location.
Additional Benefits:
Short-term incentive bonus
Long-term equity incentive (for salaried roles)
Retirement program (401k)
Paid vacation, holidays, and leaves
Medical, prescription, dental, and vision insurance
Position is at-will; compensation may be adjusted based on performance or market changes.
🔷 Equal Opportunity Statement
AstraZeneca provides equal employment opportunities to all qualified candidates, regardless of protected characteristics.
Applicants requiring accommodations may indicate their needs in the application form.
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Birmingham |Alaska :
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Chandler | Kingman | Lake Havasu City | Mesa | Peridot | Phoenix | Surprise | Tempe | Tucson | Yuma |Arkansas :
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Adelanto | Alameda | Albion | Arcata | Atherton | Berkeley | Brisbane | Burlingame | Burney | California | Carlsbad | Crescent City | Davis | Downey | El Monte | El Segundo | Emeryville | Eureka | Fortuna | Foster City | Fremont | Glendale | Hayward | Hoopa | Irvine | La Jolla | Los Angeles | Martinez | McKinleyville | Menlo Park | Millbrae | Milpitas | Morgan Hill | Mountain View | Nevada | Novato | Oakland | Orange | Pacheco | Palo Alto | Pasadena | Pleasanton | Pomona | Redding | Redwood City | Riverside | Roseville | Sacramento | San Bernardino | San Carlos | San Diego | San Francisco | San Gabriel | San Jose | San Mateo | San Rafael | Santa Clara | Santa Cruz | Santa Monica | Simi Valley | Soledad | South San Francisco | St. Helena | Stanford | Stanton | Stockton | Sunnyvale | Temecula | Thousand Oaks | Valencia | Vallejo | West Sacramento | West Valley City | Whittier | Willits |Colorado :
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Detroit | Houghton Lake | Macomb | Southfield |Minnesota :
Duluth | Eden Prairie | Fridley | Hibbing | Maple Grove | Minneapolis and St. Paul, Minnesota. | Minnetonka | St.Paul |Missouri :
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Bavaria |North Rhine Westphalia :
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Europe | France | Latvia | Lendava | Leuven | Poland | Slovenia | Spain |Finland :
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Dunboyne |Republic of Ireland :
Cork | Dublin | Limerick | Waterford |Tipperary :
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Donegal |China :
China | Quarry Bay |Hubei :
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Hangzhou |Melbourne :
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England | Harlow | Leeds | London | Maidenhead | Salt Lake City | Stevenage | Stirling | United Kingdom |Buenos Aires :
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Vienna |Antwerp :
Heist op den Berg |Brussels :
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Zaventem |Bosnia and Herzegovina :
Sarajevo |Sofia City :
Sofia |Canada :
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Renfrew | Mississauga | North York | Uxbridge | Australia | Richmond Hill |Quebec :
Montreal |Chile :
Santiago |Republic of Colombia :
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Croatia |Zagreb :
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Prague |Republic of Egypt :
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Lyon | Paris |Attica :
Koropi | Athens |Greece :
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Surabaya |Jakarta :
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Tel Aviv | Kfar Saba | Yavne | Be'Er Sheva | Netanya |Italy :
Italy |Lombardy :
Rho |Japan :
Japan | Saitama |Tokyo :
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Almaty |Remote Korea :
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Seoul |Kuala Lumpur :
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Ciudad de México |New Zealand :
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Warsaw |Remote :
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Rabigh | Riyadh | Khulais | Najran | King Abdullah Economic City | Jeddah |Nišava District :
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Madrid |Sweden :
Sweden |Taipei :
Taipei |Williamson :
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