Oncology Early Stage Clinical Scientist (Director, Non-MD) – Pfizer
Locations: La Jolla (CA), Bothell (WA), Collegeville (PA), New York City (NY), Cambridge (MA), Groton (CT), South San Francisco (CA)
Job Type: Full-Time
Job ID: 4945010
Posted: 15 Days Ago
Position Overview
Pfizer is seeking an experienced Oncology Early Stage Clinical Scientist (Director, Non-MD) to lead and coordinate clinical development activities for innovative oncology programs. This role is responsible for designing, executing, and analyzing First-in-Human (FIH), Proof of Mechanism (PoM), Early Signs of Efficacy (ESoE), and Proof of Concept (PoC) studies for both biological and small-molecule candidates.
The Director will work in close partnership with the Global Development Lead (GDL) and multidisciplinary teams to deliver early oncology development plans, oversee clinical protocol development, and ensure successful execution of clinical trials across global sites. The role requires deep scientific knowledge, strong leadership capabilities, and expertise in early oncology drug development.
This is a hybrid position, requiring on-site presence an average of 2.5 days per week.
Key Responsibilities
Clinical Strategy and Execution
Partner with the Global Development Lead to develop and implement early-stage clinical strategies for assigned assets.
Lead the design and scientific oversight of FIH, PoM, ESoE, and PoC oncology studies.
Drive high-quality clinical trial execution, including protocol development, enrollment oversight, safety review, and study delivery.
Clinical Data Analysis and Interpretation
Set the strategy for clinical data review, ensuring quality, accuracy, and consistency across studies.
Conduct clinical data analysis in collaboration with Clinical Safety, Biostatistics, and other cross-functional stakeholders.
Present emerging data to internal governance bodies, development teams, and external partners.
Cross-Functional Collaboration
Work closely with Research Units, Biostatistics, Clinical Pharmacology, Precision Medicine, Translational Oncology, and Digital Medicine.
Coordinate with Oncology Research Development (ORD) and Worldwide Research & Development (WRD) to align activities across programs.
Collaborate with biomarker, genetics, and translational science teams to integrate biomarker strategies into study designs.
Scientific Leadership and External Engagement
Serve as a technical expert for clinical and scientific questions from investigators, CROs, external consultants, and cross-functional partners.
Establish and maintain strong relationships with external experts, key opinion leaders (KOLs), investigator networks, and regulatory partners.
Support development of peer-reviewed publications, abstracts, and conference presentations.
Document Development
Lead creation of clinical protocols and contribute to documents including clinical development plans, INDs, annual reports, investigator brochures, CSRs, statistical plans, and regulatory submissions.
Departmental and Organizational Contributions
Support departmental initiatives, process improvements, and internal training.
Maintain updated knowledge of oncology clinical development trends, guidelines, and regulatory expectations.
Perform other program-related responsibilities as needed.
Minimum Qualifications and Experience Required
Education Requirements (One of the Following):
PhD or PharmD with minimum 5 years of relevant industry/CRO experience
MS with minimum 7 years of relevant industry/CRO experience
BA/BS with minimum 10 years of relevant industry/CRO experience
Experience Requirements
Strong background in Phase 1 oncology clinical research, preferably on the sponsor side.
Deep understanding of oncology drug development, especially early development.
Experience in clinical document authorship (protocols, IBs, INDs, ICDs).
Proven track record of scientific contribution (publications, posters, abstracts).
Experience with cross-functional disciplines: Clinical Operations, Regulatory, Biostatistics, Safety, Pharmacology, Data Management.
Hands-on experience reviewing clinical data listings and performing complex data analyses.
Proficiency with tools such as JReview, SpotFire, SOCs-PRO, or equivalent analytics platforms.
Strong knowledge of ICH-GCP, FDA and EMA regulations, and global clinical compliance requirements.
Preferred Qualifications
Experience leading scientific or clinical teams.
Demonstrated leadership in matrix environments, including ability to influence and collaborate across organizational levels.
Strong communication, scientific writing, analytical thinking, and decision-making skills.
Work Environment and Travel
Hybrid schedule: on-site average of 2.5 days per week.
Travel requirement: 5–10% (investigator meetings, presentations, team meetings).
Compensation and Benefits
Annual base salary range: USD 169,700 – 282,900
Eligible for Pfizer’s Global Performance Bonus (20% target)
Eligible for long-term incentive programs (share-based)
Comprehensive benefits package including:
401(k) with company contributions
Vacation, holidays, personal leave
Medical, dental, vision, and prescription coverage
Paid parental, caregiver, and medical leave
Compensation varies by location; U.S. salary range excludes Tampa, FL.
Compliance and Equal Opportunity
Pfizer complies with federal and state transparency laws, including Sunshine Act reporting.
This role requires permanent U.S. work authorization.
Pfizer is an Equal Opportunity Employer and follows all employment eligibility and nondiscrimination regulations.
Pfizer participates in E-Verify.
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