Director, Safety Risk Lead (MD) – Pfizer
Locations:
La Jolla (CA), Bothell (WA), Collegeville (PA), New York City (NY), Cambridge (MA), Groton (CT), South San Francisco (CA)
Employment Type: Full-Time
Job ID: 4945593
Position Overview
Pfizer is seeking an experienced Director, Safety Risk Lead (MD) to support global medical safety oversight across the company’s portfolio. This role is responsible for evaluating safety data, detecting and assessing safety signals, and guiding benefit-risk management activities throughout the product lifecycle. The position requires strong medical judgment, leadership capabilities, and a deep understanding of pharmacovigilance principles.
The Director will lead safety surveillance activities, collaborate with cross-functional teams, and engage with internal and external stakeholders to ensure patient safety and regulatory compliance.
This hybrid role requires residency within commuting distance to one of the listed Pfizer sites and on-site presence for an average of 2.5 days per week.
Key Responsibilities
Safety Leadership and Risk Management
Serve as the primary safety point of contact for assigned assets and therapeutic areas.
Chair Risk Management Committees (RMCs) and Core Working Groups with minimal oversight.
Conduct proactive safety surveillance, signal detection, evaluation, and benefit-risk assessments.
Develop and implement action plans to address identified risks and support risk minimization strategies.
Cross-Functional Collaboration
Represent Safety Surveillance & Risk Management (SSRM) in internal governance forums and regulatory interactions.
Work closely with Medical, Clinical, Regulatory, Quality, and Corporate Audit teams to support unified benefit-risk communication.
Collaborate with global and regional teams to ensure consistent safety messaging across products and indications.
Scientific and Strategic Contributions
Provide disease-area expertise, particularly in Oncology (preferred).
Review and approve key safety documents, safety summaries, and benefit-risk reports.
Contribute to due diligence activities and coach colleagues on safety assessment approaches.
Support inspection readiness and contribute data for audit and compliance reporting.
Innovation and Process Excellence
Identify opportunities to enhance safety surveillance methodologies and implement process improvements.
Participate in Safety Science Research, communication initiatives, and continuous improvement projects.
Mentor junior colleagues and foster a culture of quality, collaboration, and scientific excellence.
Required Qualifications
Medical Degree (MD or DO) or equivalent.
Minimum 4 years of relevant experience, which may include:
Patient care or clinical practice
Clinical trial oversight
Academic medicine
Pharmacovigilance
Drug development
Demonstrated experience in safety evaluation, signal detection, and benefit-risk assessment.
Strong understanding of global safety regulations and the drug development lifecycle.
Proven ability to influence cross-functional teams and lead in a matrixed environment.
Excellent verbal, written, and scientific communication skills.
Ability to manage complex workloads, prioritize effectively, and operate with scientific independence.
Preferred Qualifications
Disease-area expertise in Oncology.
Prior experience in Field Medical or global pharmacovigilance roles.
Familiarity with internal and external safety-related regulatory requirements.
Understanding of statistical principles and analytical tools used in safety analysis.
Work Requirements
Hybrid schedule: on-site 2.5 days per week on average.
Travel may be required depending on business needs.
Must have permanent authorization to work in the United States.
Compensation and Benefits
Salary Range: USD 219,800 – 366,400 annually.
Eligible for:
Pfizer Global Performance Plan (bonus target 25% of base salary)
Long-term incentive program
401(k) with matching contributions and retirement savings plan
Comprehensive medical, dental, vision, prescription drug coverage
Paid vacation, holidays, personal days, caregiver and parental leave
Compensation varies by location in the United States.
Relocation assistance may be available based on role eligibility.
Equal Opportunity Statement
Pfizer is committed to providing equal employment opportunities without discrimination based on race, color, religion, sex, gender identity, sexual orientation, national origin, age, disability, or veteran status. Pfizer is an E-Verify employer and complies with all applicable employment eligibility regulations.
Application Deadline
Last Date to Apply: December 09, 2025
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