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Associate Medical Safety Director

3 years
Not Disclosed
10 Nov. 14, 2025
Job Description
Job Type: Full Time Hybrid Education: B.Sc./ M.Sc./ M.Pharm/ B.Pharm/ Life Sciences Skills: Causality Assessment, Clinical SAS Programming, Communication Skills, CPC Certified, GCP guidelines, ICD-10 CM Codes, CPT-Codes, HCPCS Codes, ICD-10 CM, CPT, HCPCS Coding, ICH guidelines, ICSR Case Processing, Interpersonal Skill, Labelling Assessment, MedDRA Coding, Medical Billing, Medical Coding, Medical Terminology, Narrative Writing, Research & Development, Technical Skill, Triage of ICSRs, WHO DD Coding

Job Title: Associate Medical Safety Director

Job Overview

The Associate Medical Safety Director provides medical expertise for pharmacovigilance services across assigned clinical trials and standalone safety projects. The role involves comprehensive medical review, safety oversight, and regulatory contributions, with supervision from senior medical safety leadership as needed.


Essential Functions

1. Adverse Event & Case Review

  • Conduct medical review and clarification of trial-related Adverse Events (AEs) and post-marketing Adverse Drug Reactions (ADRs).

  • Assess narrative content, queries, coding, expectedness, seriousness, causality, and prepare company summaries.

  • Prepare and medically review Analyses of Similar Events (AOSE) for expedited cases based on regulatory requirements.

2. Pharmacovigilance Case Processing Support

  • Serve as an internal medical consultant for pharmacovigilance case processing teams.

  • Provide coding review for AEs, past medical history, concomitant medications, and other medical data listings.

3. Safety Oversight & Aggregate Review

  • Conduct aggregate reviews of safety information and clinical data to maintain up-to-date safety profiles.

  • Present safety and clinical data review findings during client and project meetings.

4. Regulatory Submissions & Reports

  • Provide medical review and edits for:

    • IND Annual Reports

    • EU Periodic Benefit-Risk Evaluation Reports (PBRERs)

    • EU Periodic Safety Update Reports (PSURs)

    • Development Safety Update Reports (DSURs)

    • US Periodic Reports

  • Contribute to Development Risk Management Plans (RMPs), EU RMPs, and US REMS programs.

  • Provide medical oversight for product label development, review, and updates.

5. Safety Governance & Committees

  • Provide medical support during Data Safety Monitoring Board (DSMB) meetings.

  • Participate in Safety Monitoring Committees with medical safety evaluations.

  • Contribute medical safety expertise to Integrated Safety Summaries and Common Technical Documents.

6. Project Documentation & Protocol Review

  • Review and approve Project Safety Plans and Medical Monitoring Plans.

  • Perform medical safety review of protocols, Investigator’s Brochures (IB/IDB), and Case Report Forms (CRFs) for appropriate safety content.

7. Medical Representation & Escalation

  • Act as Global Safety Physician, Assistant, or Backup Physician as assigned.

  • Provide medical escalation support for:

    • Medical information projects

    • EU Qualified Persons for Pharmacovigilance (QPPV)

  • Ensure 24-hour medical support coverage for assigned projects.

8. Meetings & Cross-Functional Collaboration

  • Attend project meetings, medical safety team meetings, and client meetings.

  • Ensure timely delivery of all medical safety commitments per contracted or regulatory timelines.

9. Continuous Learning

  • Maintain awareness of industry developments in medical, safety, and regulatory domains.


Qualifications

Education

  • Medical degree (MBBS/MD or equivalent) from a globally accredited and recognized medical institution.

Experience

  • Minimum:

    • 3 years of clinical practice/graduate medical training, and

    • 2 years of experience in the pharmaceutical or related industry
      OR

    • Equivalent combination of education, training, and experience.

Knowledge & Skills

  • Strong knowledge of federal and local regulations related to clinical research, safety, and Good Clinical Practice (GCP).

  • Understanding of clinical trials and the pharmaceutical research process.

  • Ability to prioritize tasks, meet deadlines, and manage multiple objectives.

  • Strong consulting, problem-solving, and decision-making skills.

  • Effective interpersonal skills with ability to build relationships with colleagues, managers, and clients.