Advisor/Senior Advisor - Process Chemistry - Synthetic Peptide Chemistry (Smdd)

7+ years

Not Disclosed

Indianapolis

10 Jan. 30, 2025

Job Description

Job Type: Full Time Education: B.Sc, M.Sc, B.Pharm, M.Pharm, LifeScience Graduates Skills: Causality Assessment, Clinical SAS Programming, Communication Skills, CPC Certified, GCP guidelines, ICD-10 CM Codes, CPT-Codes, HCPCS Codes, ICD-10 CM, CPT, HCPCS Coding, ICH guidelines, ICSR Case Processing, Interpersonal Skill, Labelling Assessment, MedDRA Coding, Medical Billing, Medical Coding, Medical Terminology, Narrative Writing, Research & Development, Technical Skill, Triage of ICSRs, WHO DD Coding

Job Title: Advisor/Senior Advisor - Process Chemistry - Synthetic Peptide Chemistry (SMDD)
Location: Indianapolis, Indiana, United States
Category: Research & Development
Job Type: Full Time, Regular
Job Id: R-77884

About Eli Lilly:

At Eli Lilly and Company, we unite caring with discovery to make life better for people around the world. As a global healthcare leader, we are dedicated to discovering and delivering life-changing medicines, improving disease management, and giving back to the communities we serve. We value our employees and strive to provide an inclusive, supportive, and innovative work environment.

Position Overview:

The Synthetic Molecule Design and Development (SMDD) organization at Eli Lilly is seeking a highly skilled and innovative synthetic organic chemist to join our peptide process development team. This team plays a crucial role in the sustainable development and commercialization of therapeutic peptides. The successful candidate will be involved in cutting-edge peptide chemistry, process optimization, and will collaborate across teams to deliver high-quality peptide active pharmaceutical ingredients (APIs).

This is an exciting opportunity to be part of a dynamic, cross-functional team that has already successfully commercialized peptide drugs like Mounjaro/Zepbound (Tirzepatide Hybrid Synthesis). The position will involve using established and novel technologies in synthetic peptide chemistry and manufacturing processes.

Responsibilities:

Peptide Synthesis: Synthesize complex peptide APIs using established and innovative techniques, including continuous manufacturing.
Process Development: Design and implement sustainable, innovative, and cost-effective synthetic processes for API production.
Problem Solving: Apply problem-solving skills to overcome challenges in peptide synthesis and process optimization.
Collaboration: Work with external organizations for technology transfer and process improvements, ensuring seamless support for the commercialization process.
Green Chemistry: Embrace principles of green chemistry to minimize the environmental impact of peptide manufacturing processes.
Data Generation & Regulatory Support: Generate data for regulatory filings and contribute to the development of high-quality documentation.
Knowledge Sharing: Present research findings in internal forums, at conferences, and through peer-reviewed journals.

Minimum Qualifications:

Education: PhD in Chemistry or a related field, or MS in Chemistry with at least 7+ years of relevant experience.
Experience: Strong background in synthetic organic chemistry and/or peptide chemistry.
Analytical Skills: Experience with peptide characterization techniques such as NMR, HPLC, and MS.
Peptide Synthesis Techniques: Understanding of various peptide synthesis methods, including Solid-Phase Peptide Synthesis (SPPS), Solution-Phase Peptide Synthesis (LPPS), and enzymatic approaches.
Technical Skills: Expertise in synthetic organic chemistry methods, chromatography (reverse-phase, ion exchange, size exclusion, chiral), and mass spectrometry (MS) for characterization.
Collaboration: Strong experience working in multidisciplinary, cross-functional teams.
Communication: Strong written and verbal communication skills with the ability to effectively present research.

Desirable Skills/Preferences:

Familiarity with peptide automation and advanced synthetic methods.
Knowledge of structural/molecular properties and their role in reaction development.
Proven ability to meet deadlines and manage multiple assignments.
Strong publication record, particularly in organic synthesis or peptide chemistry.

Additional Information:

Travel: Minimal (0-10% travel)
Exposure: Possible exposure to chemicals, allergens, and loud noises in the laboratory.
Work Environment: This position will be based at the Lilly Technology Center-North, Indianapolis, Indiana.

Work-Life Balance and Benefits:

At Eli Lilly, we value work-life balance and offer flexible working hours, remote work opportunities, and a comprehensive benefits package. This includes health insurance, paid time off, 401(k) participation, life insurance, and employee well-being programs.

Diversity, Equity, and Inclusion:

Eli Lilly is committed to fostering an inclusive environment where all employees are respected and supported. We offer various employee resource groups and initiatives, such as those focused on professional advancement and personal well-being.

Lilly is an EEO/Affirmative Action Employer and does not discriminate based on age, race, color, religion, gender, sexual orientation, gender identity, national origin, disability, or veteran status.

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