Job Title
Senior Principal Scientist, Preclinical Safety & Translational Sciences – Translational Pharmacokinetics/Pharmacodynamics
Company
Johnson & Johnson
Locations
Spring House, Pennsylvania, United States of America
San Diego, California, United States of America
Work Pattern
Hybrid Work
Job Function
Discovery & Pre-Clinical/Clinical Development
Job Sub-Function
Pharmacokinetics & Pharmacometrics
Job Category
Senior Principal Scientist, Pharmacokinetics & Pharmacometrics (ST8)
Requisition Number
R-018732
Date Posted
August 29, 2025
Application Deadline
September 30, 2025 (may be extended)
Company Overview
Johnson & Johnson’s Innovative Medicine segment leverages patient insights to drive science-based advancements that lead to life-saving medicines. The team works to develop new treatments and cures, moving innovations from the lab to patients. Learn more at jnj.com/innovative-medicine.
Position Purpose
As a Senior Principal Scientist, you will be a key contributor on discovery project teams, collaborating with biology, chemistry, and drug metabolism/pharmacokinetics (DMPK) colleagues. You will lead the design and application of quantitative modeling—including physiologically-based pharmacokinetic (PBPK), mechanistic PK/PD, and systems pharmacology modeling—to:
Predict preclinical and clinical pharmacokinetic profiles
Quantify exposure-response relationships for target engagement biomarkers, efficacy, and safety
Guide in vivo and in vitro experimental designs for optimal data generation
Key Responsibilities
Lead application of PK/PD modeling to inform project decisions from early discovery through early clinical stages.
Contribute to the development and implementation of modeling and simulation strategies organization-wide.
Collaborate cross-functionally to support candidate selection, dosing recommendations, and experimental design.
Qualifications
Education
PhD in Pharmacology, Engineering, Mathematics, Physics, or related field with 6+ years relevant industry experience, OR
Master’s degree with 8+ years relevant industry experience.
Experience & Skills
Strong understanding of pharmacokinetics and pharmacodynamics principles.
Experience performing PK and/or PK/PD modeling preferred.
Proven mathematical modeling and simulation expertise (peer-reviewed publications highly desirable).
Excellent interpersonal, organizational, communication (oral and written), and teamwork skills.
Other
Position may require up to 10% travel.
Compensation
Base salary range: $137,000 – $235,750
Eligible for annual performance-based cash bonus (discretionary, based on individual and company performance).
Benefits
Medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, group legal insurance.
Retirement plans including pension and 401(k).
Paid time off including vacation (up to 120 hours/year), sick leave (up to 40 hours/year; 56 hours/year for Washington state employees), holidays (up to 13 days/year), and personal/family time (up to 40 hours/year).
More details at: Johnson & Johnson Employee Benefits
Equal Employment Opportunity
Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will be considered regardless of race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status, or other protected characteristics. Accommodations are available upon request.
For accommodation requests, contact:
Employee Health Support Center – ra-employeehealthsup@its.jnj.com
AskGS – accommodation resource
Additional Notes
The posting may remain open beyond the listed close date to accept additional applications.
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Hajipur | Patna |Kerala :
Kannur | Kochi | Malappuram | Thiruvananthapuram | Trivandrum |Pondicherry (Puducherry) :
Pondicherry (Puducherry) |Jharkhand :
Ranchi |Sikkim :
Rangpo |India :
Siliguri |Illinois :
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Appleton | Kenosha | Pleasant Prairie | Portage | Waukesha |United states :
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Frank Scottile Blvd |Missouri :
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Kyiv |Lima Region :
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