Principal Scientist

6+ years

$117,700 - $218,500

Remote, USA Washington

10 Feb. 13, 2025

Job Description

Job Type: Remote Education: B.Sc./ M.Sc./ M.Pharm/ B.Pharm/ Life Sciences Skills: Causality Assessment, Clinical SAS Programming, Communication Skills, CPC Certified, GCP guidelines, ICD-10 CM Codes, CPT-Codes, HCPCS Codes, ICD-10 CM, CPT, HCPCS Coding, ICH guidelines, ICSR Case Processing, Interpersonal Skill, Labelling Assessment, MedDRA Coding, Medical Billing, Medical Coding, Medical Terminology, Narrative Writing, Research & Development, Technical Skill, Triage of ICSRs, WHO DD Coding

Job Title: Principal Scientist

Location: Seattle, Washington, United States of America
Category: Research & Development
Job ID: 202410-125730

Position Overview

At Roche, we advance science to create a healthier future for everyone. We are committed to advancing DNA sequencing technology through the acquisition of Stratos Genomics in 2020, which brought Sequencing by Expansion (SBX™) technology to the forefront. This unique chemistry revolutionizes nanopore sequencing by translating DNA sequences into measurable surrogates, significantly enhancing accuracy and throughput.

As a Principal Scientist, you will play a key role in the Molecular Engineering group, working on developing and synthesizing the building blocks for this groundbreaking technology. Your work will directly contribute to advancing DNA sequencing and improving patient outcomes. We're looking for someone with a deep technical background, leadership skills, and a passion for making SBX technology a success.

Key Responsibilities:

Research and Experimentation:
- Design and execute well-controlled experiments with high attention to detail.
- Lead innovative research and troubleshoot complex problems creatively.
- Contribute to the definition and achievement of project goals.
Leadership and Mentorship:
- Lead cross-functional teams, mentoring junior team members and ensuring they are equipped to perform at their best.
SOP Development and Reagent Production:
- Develop Standard Operating Procedures (SOPs) to streamline the production of reagents and starting materials.
- Participate in the production of reagents, ensuring quality and consistency.
Data Analysis & Protocol Development:
- Conduct thorough data analysis and support the development of lab protocols.
- Maintain accurate and reliable laboratory records.
Collaboration & Presentation:
- Present findings and progress at group or departmental meetings.
Lab Maintenance:
- Maintain the lab’s cleanliness, organization, and safety.
Process Improvement:
- Continuously propose and implement process improvements to enhance lab functions and outcomes.

Who You Are

Educational Qualifications:
- Bachelor’s Degree in Organic Synthesis, Chemistry, Chemical Engineering, Biochemistry, or a related field with 10+ years of experience.
- Master’s Degree in a related field with 9+ years of experience.
- PhD in a related field with 6+ years of experience.
Technical Expertise:
- 6+ years of laboratory experience in advanced nucleotide/heterocyclic chemistry, phosphorus chemistry, or complex/multi-step organic synthesis.
- Strong understanding and experience with the chemistry of nucleotides, phosphoramidites, heterocycles, amino acids, and bio-conjugations.
- Solid background in next-generation DNA sequencing (NGS).
- Experience working with HPLC, MS, NMR, automated DNA synthesizers, inert atmosphere chambers, and manual pipetting.
Preferred Experience:
- Familiarity with SBX technology, nanopore sequencing, and other emerging technologies in DNA sequencing.
Skills & Competencies:
- Strong leadership, mentorship, and team collaboration skills.
- Ability to work independently and thrive in a fast-paced, dynamic environment.
- Excellent problem-solving and troubleshooting abilities.
- Deep understanding of chemical and biochemical sample handling, reactivity, purification, and storage.

Why Roche?

Roche is at the forefront of advancing healthcare through science and technology. As a Principal Scientist, you will be working on pioneering SBX technology, contributing to the development of next-generation sequencing methods that can transform patient outcomes. This is a rare opportunity to make a significant impact on healthcare while working in a collaborative and innovative environment.

Additional Information:

Salary Range: $117,700 - $218,500 (based on experience, qualifications, geographic location, and other job-related factors).
Discretionary Annual Bonus: Available based on individual and company performance.
Relocation Benefits: Available for this position.

Note: Please include a cover letter outlining why you want to work with Roche, your specific technical interest in SBX technology, and how you would contribute to the team. This is an important part of the application process.

How to Apply

If you're ready to lead innovative research, contribute to the development of revolutionary technology, and be part of a world-class team, apply today for the Principal Scientist position at Roche. Join us in advancing DNA sequencing for a healthier tomorrow!

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Principal Scientist

Job Description

Job Title: Principal Scientist

Position Overview

Key Responsibilities:

Who You Are

Why Roche?

Additional Information:

How to Apply

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