Scientist / Senior Scientist – Oligonucleotide Analytics
Location: Indianapolis, Indiana, USA
Category: Research & Development
Job Type: Full Time | Regular
Job ID: R-95828
About the Company
Lilly is a global leader in pharmaceutical innovation, dedicated to improving health outcomes through scientific discovery and advanced therapeutic development. With headquarters in Indianapolis and a worldwide research network, Lilly focuses on developing impactful medicines and delivering meaningful contributions to global healthcare. The organization values scientific excellence, operational integrity, and a people-first culture.
Position Overview
Lilly’s LIGM RNA Group is seeking a skilled and independent Scientist or Senior Scientist specializing in oligonucleotide analytics. This laboratory-based role requires extensive hands-on expertise in LC/MS, analytical method development, and the characterization of oligonucleotides and conjugates. The ideal candidate will demonstrate strong scientific agility, problem-solving capabilities, and proven experience in applying cutting-edge analytical technologies in fast-paced research environments.
Key Responsibilities
Conduct sample preparation for forced degradation and solution stability studies supporting early-stage developability assessments of oligonucleotides and their conjugates.
Characterize solubility and evaluate physical and chemical stability using chromatography, mass spectrometry, thermal analysis, microscopy, light scattering, particle counting, and imaging technologies.
Develop and optimize LC/LCMS-based analytical methods to identify impurities and degradants from API and stability samples.
Partner with cross-functional teams including Early Phase TIDES and Discovery to support analytical packages for method and project transfers.
Identify technical risks and propose mitigation strategies to support drug candidate performance and development.
Drive innovation through learning agility, novel analytical approaches, and cross-disciplinary scientific contributions.
Engage and influence external scientific partners to enhance collaborations and strengthen Lilly’s internal portfolio.
Continuously refine analytical workflows and develop new assays to meet program requirements.
Ensure timely documentation of experimental plans, data, and technical reports in electronic laboratory notebooks.
Support high laboratory standards with a focus on safety, quality, and operational excellence.
Present analytical findings and progress updates in project, departmental, and governance meetings.
Experience Required
Master’s degree (M.S.) in Chemistry, Analytical Chemistry, Biophysics, Biochemistry, or a related field with a minimum of 5 years of hands-on experience in LC/MS analytical characterization,
OR
Bachelor’s degree (B.S.) with at least 8 years of relevant experience in LC/MS-based analytical characterization.
Proven expertise in analytical method development for oligonucleotides and conjugates.
Demonstrated experience with large-scale sample preparation, automated workflows, and analytical instrumentation.
Strong problem-solving skills and ability to learn and apply new analytical technologies rapidly.
Ability to work independently while delivering high-quality results in fast-paced environments.
Experience presenting scientific results and collaborating within multidisciplinary teams.
Preferred Skills
Knowledge of biopharmaceutics, pharmacokinetics, and phase-appropriate formulation development.
Experience with analytical characterization of oligonucleotides, conjugates, and biologics.
Proficiency in separation sciences including RP, HILIC, HIC, IEX, SEC, and CE.
Expertise with mass spectrometry platforms such as QToF, Orbitrap, and QQQ.
Familiarity with advanced imaging and biophysical techniques including light scattering, BLI, and backgrounded membrane imaging.
Strong communication, documentation, and scientific writing skills.
Additional Information
This position requires eligibility to work in the United States; sponsorship is not available.
Lilly offers accommodations for applicants with disabilities through a dedicated support process.
Salary range: USD 65,250 – 169,400, based on experience, skills, and location.
Full-time employees are eligible for performance-based bonuses and a comprehensive benefits package, including health coverage, retirement programs, paid time off, and wellness resources.
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