Scientific Director, Biotherapeutics Design & Optimization

7+ years

Not Disclosed

Indianapolis

10 Jan. 29, 2025

Job Description

Job Type: Full Time Education: B.Sc, M.Sc, B.Pharm, M.Pharm, LifeScience Graduates Skills: Causality Assessment, Clinical SAS Programming, Communication Skills, CPC Certified, GCP guidelines, ICD-10 CM Codes, CPT-Codes, HCPCS Codes, ICD-10 CM, CPT, HCPCS Coding, ICH guidelines, ICSR Case Processing, Interpersonal Skill, Labelling Assessment, MedDRA Coding, Medical Billing, Medical Coding, Medical Terminology, Narrative Writing, Research & Development, Technical Skill, Triage of ICSRs, WHO DD Coding

Job Title: Scientific Director, Biotherapeutics Design & Optimization
Location: Indianapolis, Indiana, United States
Category: Research & Development
Job Type: Full-Time, Regular
Job ID: R-79325

Company Overview

At Lilly, we unite caring with discovery to make life better for people around the world. As a global healthcare leader headquartered in Indianapolis, Indiana, our employees work together to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We are committed to a culture where individuals are empowered to make a difference in the lives of others.

Position Overview

Lilly's Biotechnology Discovery Research (BioTDR) organization is seeking a highly skilled and experienced Scientific Director to join our Biotherapeutic Lead Optimization team. This role offers an exciting opportunity to work on the development of innovative biotherapeutic medicines, including monoclonal antibodies (mAbs), bispecific antibodies (bsAbs), proteins, and bioconjugates. The successful candidate will lead cutting-edge biotherapeutic design and engineering projects from concept to clinical development. This position requires a deep understanding of the large molecule drug discovery and development process, as well as disease biology.

Key Responsibilities

Lead and manage biotherapeutic design and engineering projects, guiding them from concept through to clinical development.
Oversee the development of mAbs, bsAbs, proteins, and bioconjugates, integrating innovative approaches to ensure therapeutic success.
Collaborate with cross-functional teams to drive large molecule drug discovery and development.
Provide scientific expertise and influence portfolio and project strategy.
Mentor and develop junior scientists, fostering the growth of the team.
Stay current with emerging trends and technologies in biologics and bioconjugates.
Represent Lilly at scientific conferences and build external collaborations to enhance the company's research initiatives.

Basic Qualifications

PhD in Biochemistry, Bioengineering, Molecular Biology, or a related field.
Minimum of 7 years of relevant experience in biotherapeutics research and development.
Proven expertise in lead discovery and optimization for various biologic formats, including antibodies, multispecific antibodies, fusion proteins, and bioconjugates.
Demonstrated success in delivering clinical candidates across diverse therapeutic areas.
In-depth understanding of large molecule drug discovery and development processes.
Expertise in protein design, protein-protein interactions, structure-function relationships, and biophysical characterization.
Strong knowledge of developability assessment methods (e.g., stability, solubility, manufacturability).
Supervisory and talent management experience.

Preferred Qualifications

Experience collaborating with computational and discovery teams to optimize biologics for a range of indications.
Familiarity with automation and high-throughput workflows.
Expertise in protein structure analysis tools (e.g., Pymol, Chimera, MOE).
Strong verbal and written communication skills.
Excellent organizational and time management skills with the ability to adapt to shifting priorities and deadlines.
Ability to work effectively across organizational boundaries to solve complex technical and business challenges.

Additional Information

Location: Indianapolis, Indiana, USA
Travel: 0-10%
Compensation: The anticipated salary for this position ranges from $144,000 to $250,800, depending on the candidate’s education, experience, skills, and geographic location.

Lilly is an Equal Opportunity/Affirmative Action Employer and does not discriminate based on age, race, religion, gender, sexual orientation, gender identity, disability, or any other legally protected status.

Benefits:
Eligible employees will receive comprehensive benefits, including medical, dental, and vision coverage, flexible spending accounts, retirement plans (401k and pension), vacation, wellness programs, life insurance, and more.

If you're passionate about driving biotherapeutic innovation and making a meaningful impact on human health, we encourage you to apply today.

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Scientific Director, Biotherapeutics Design & Optimization

Job Description

Company Overview

Position Overview

Key Responsibilities

Basic Qualifications

Preferred Qualifications

Additional Information

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