Principal Scientist - Protein Discovery and Engineering
Location: Lexington, United States
Job Category: Research
About the Department
Our Research & Development organization brings together the best minds in life science innovation. The teams located in facilities in Lexington, Watertown, Cambridge, and Seattle reflect the full R&D continuum, from early research through late-stage clinical development. Here, we are building for the future, creating a distinct R&D community based on collaboration, partnerships, and cutting-edge research across multiple modalities and therapeutic areas. We recognize that improving human health starts here and that patients rely on us. Our R&D hub merges biotech speed and agility with large pharmaceutical company quality, resources, and stability, uniting the best of both worlds to develop new medicines for patients.
As part of the establishment of our R&D Hub in greater Boston, Novo Nordisk is growing its efforts within Chemical Biology. A cornerstone of this is an expansion of our capabilities in protein discovery and engineering to support the validation of drug targets and advance drug research programs that address unmet needs within a broad range of serious chronic diseases. Building on our success in delivering treatments for diabetes, obesity, and other chronic and rare diseases, we are rapidly growing our activities in pursuit of next-generation therapies and exploring new targets across new modalities.
In growing our presence in the greater Boston area, we seek to combine Novo Nordisk's 100-year heritage with the innovation ecosystem of Boston. As a member of this vibrant team, you will help develop the next generation of medicines. If you want to make a difference, join us in pioneering research that can have a global impact.
The Position
As a Principal Scientist, you will be responsible for building up protein design and expression capabilities, as well as various technology platforms for therapeutic protein discovery and engineering. These efforts will support target validation and drug discovery projects. You will lead protein innovation, lab-scale protein production, and project coordination. Your responsibilities include advancing scientific ideas into projects through experimental design, ensuring data integrity and reproducibility, and communicating results to diverse project teams.
Collaboration is key, as you will work closely with scientists within the Chemical Biology team, other teams across our growing US R&D Hub, and global project teams. The dynamic and innovative environment in R&ED provides an excellent opportunity to establish a strong global scientific network.
Relationships
Internal Relationships:
Project teams and research colleagues in the greater Boston area and at research sites in the US, Denmark, China, and the UK.
Reports to the Head of Chemical Biology.
Individual Contributor: Does not manage other employees or contingent workers.
Essential Functions
Technology Platforms: Establish protein discovery and engineering platforms, including mammalian, insect, E. coli, yeast, or other cell-based expression systems, as well as cell-free expression systems such as in vitro transcription and translation.
Laboratory Automation: Apply cutting-edge techniques in laboratory automation to maximize throughput in protein discovery and engineering workflows.
Project Coordination: Lead and manage projects, including technical coordination and project management.
Autonomous Work: Work with full autonomy on complex tasks, linking long-term business needs to short-term research goals.
Subject Matter Expertise: Serve as a subject matter expert in protein discovery and engineering, solving complex problems and contributing beyond your area of expertise.
External Collaborations: Propose and manage external collaborations and strategic partnerships, particularly in the academic and biotech communities.
Scientific Ambassadorship: Represent Novo Nordisk in the protein sciences field through patents, publications, and scientific conferences.
Mentorship: Mentor junior scientists to enhance the team’s scientific acumen and create a strong team culture.
Data Integrity: Ensure data integrity to meet FAIR data standards, enabling efficient decision-making and long-term data utilization.
Physical Requirements
0-10% overnight travel required.
Qualifications
Education: Master’s degree with 12+ years or a PhD with 8+ years of relevant experience in biological, biochemical, or pharmacological sciences.
Experience:
Key role in protein drug discovery evidenced through patents and publications.
Extensive experience in protein design, construct design, protein expression, and characterization.
Expertise in high-throughput protein discovery platforms and automated workflows.
Knowledge of the drug research process from ideation to lead candidate selection.
Familiarity with bioconjugation, protein biophysical characterization, and structural biology techniques.
Technical Skills:
Experience with industry-standard laboratory equipment and instrumentation.
Familiarity with data processing tools such as Prism, Python, and R.
Proficient in protein structure prediction, modeling, and computational design.
Communication Skills: Strong verbal and written communication skills.
Novo Nordisk is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex, gender identity, sexual orientation, national origin, disability, protected veteran status, or any other characteristic protected by local, state, or federal laws.
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