Job Title:
Precision Medicine Director – Obesity & Cardiometabolic Disorders
Location:
📍 US – California – South San Francisco
💼 Work Type: On Site
Job Details:
Job ID: R-221640
Category: Research
Date Posted: August 5, 2025
Salary Range: Not specified (based on experience and qualifications)
About Amgen:
At Amgen, we are driven by a powerful mission: to serve patients living with serious illnesses. Since 1980, we’ve been pioneering in biotechnology, focusing on Oncology, Inflammation, General Medicine, and Rare Disease. Our work reaches millions globally and is rooted in science, collaboration, and innovation.
Join us and make a real difference—transform patients’ lives while transforming your career.
Role Summary:
In this Director-level role, you will lead precision medicine and translational science strategies for early-stage programs focused on obesity and cardiometabolic disorders. You’ll collaborate across functions to drive biomarker strategy, integrate multi-omics data, and guide preclinical assets from discovery through IND and into first-in-human (FIH) studies.
Key Responsibilities:
🔬 Biomarker & Data Strategy
Design and lead biomarker strategies for pharmacodynamics, target engagement, and MoA indicators.
Leverage high-dimensional datasets (e.g., genomics, proteomics, single-cell data) to inform patient stratification and target validation.
🧪 Strategic Leadership in Early Development
Serve as a senior translational leader, embedding biomarker and MoA strategies early in research programs.
Enable first-in-human (FIH) readiness and proof-of-concept (PoC) through strategic decision-making.
🔄 Integration Across Discovery & Early Clinical Development
Act as a bridge between discovery and early clinical teams to align translational hypotheses and biomarker strategy.
Ensure preclinical data supports IND and early clinical development.
🔁 Mechanistic & Reverse Translational Research
Develop reverse translational approaches to understand mechanisms of resistance and disease heterogeneity.
Generate hypotheses related to drug MoA and patient subpopulations.
🤝 Cross-Functional Collaboration
Partner with teams in Discovery Research, PKDM, Clinical Development, Regulatory Affairs, and more.
Support seamless transition from IND-enabling studies to clinical trial initiation.
🌐 External Innovation & Partnerships
Build and maintain collaborations with academic institutions, biotech companies, and consortia.
Integrate innovative tools and platforms into Amgen’s precision medicine ecosystem.
🧭 Strategic Contributions at the TA Level
Influence therapeutic area strategy, including target prioritization, combination therapies, and endotype definitions.
👥 Mentorship & Team Leadership
Mentor and lead a team of biomarker scientists, ensuring scientific rigor and career development.
Provide strategic and scientific oversight to direct reports and project teams.
Qualifications:
✅ Basic Qualifications (one of the following):
Doctorate degree + 4 years of relevant experience
Master’s degree + 7 years of relevant experience
Bachelor’s degree + 9 years of relevant experience
🌟 Preferred Qualifications:
PhD or MD/PhD with 6+ years of progressive translational research experience in obesity or cardiometabolic diseases.
Leadership experience taking programs from research through IND submission.
Experience as biomarker lead on clinical-stage assets with strong mechanistic knowledge in:
Obesity biology
Insulin resistance
Dyslipidemia
Cardiovascular disease
Proven record of scientific contributions via publications, conferences, or industry leadership.
Expertise in:
Multi-omics
Biomarker discovery and validation
Patient stratification
Strategic thinker with ability to synthesize complex data for decision-making.
Skilled in cross-functional leadership and communication in matrixed environments.
Prior experience mentoring or managing junior scientists.
What You Can Expect from Amgen:
💵 Compensation & Benefits
Competitive base salary (based on experience; not publicly listed)
Annual bonus or incentive plan
Stock-based long-term incentives
Retirement and Savings Plan with company contributions
Comprehensive insurance: Medical, dental, vision, life, disability
Flexible Spending Accounts (FSAs)
Award-winning paid time off plans
Flexible work models where possible
Application Notes:
No application deadline; applications accepted until filled.
You may redact age-identifying information (e.g., birthdate, graduation years) in your submission. This will not affect your candidacy.
Equal Opportunity Statement:
Amgen is an Equal Opportunity Employer. All qualified applicants will be considered without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran status, disability, or any other protected characteristic.
We are committed to providing accommodations during the hiring process for individuals with disabilities. Please contact us to request support.
How to Apply:
🔗 Visit careers.amgen.com
📤 Apply for Job ID: R-221640
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