Job Title:
Executive Medical Director – US Medical Affairs Lead
Therapeutic Area: Thyroid Eye Disease (TED)
Location:
📍 Thousand Oaks, California, USA
💼 Remote Work Option Available
Job Details:
Job ID: R-223832
Category: Medical Affairs
Date Posted: August 25, 2025
Work Type: Remote
Salary Range: $343,334 – $403,728 USD annually
About Amgen:
Amgen is a global leader in biotechnology, with a mission to serve patients living with serious illnesses. Since 1980, Amgen has pioneered therapies in Oncology, Inflammation, General Medicine, and Rare Disease. The company is dedicated to innovation, scientific excellence, and transforming patient outcomes through its world-class medicines and collaborative, values-driven culture.
Position Summary:
The Executive Medical Director, US Medical Affairs Lead will lead the medical strategy and execution for TEPEZZA® (teprotumumab-trbw)—the first and only FDA-approved treatment for Thyroid Eye Disease (TED)—as well as other pipeline products in this franchise.
You will be responsible for maximizing Amgen’s value proposition through medical strategy, stakeholder engagement, evidence generation, and scientific communication.
Key Responsibilities:
🔹 Strategic Leadership
Develop and execute the US medical affairs strategy for TEPEZZA and TED franchise.
Guide product strategy and pipeline development within the TED franchise.
Lead the external stakeholder strategy including KOL engagement, medical education, and communication.
🔹 Scientific Communication
Oversee the development and execution of the US medical communication plan:
Scientific platform and core content
Publications and congress planning
Clinical narrative framework
🔹 Stakeholder Engagement
Engage with US external stakeholders to build awareness of the unmet need and medical value of TEPEZZA and related pipeline products.
Elevate Amgen’s reputation as a science-based, patient-focused partner.
🔹 Evidence Generation & Internal Collaboration
Collaborate cross-functionally on evidence generation, ensuring regional/local insights inform global strategy.
Provide actionable medical insights to internal partners across Commercial, Regulatory, Clinical, and Medical Affairs teams.
About TEPEZZA (Teprotumumab-trbw):
TEPEZZA is a monoclonal antibody targeting IGF-1R, approved for the treatment of TED. It is a breakthrough biologic that improves inflammation, orbital tissue expansion, and proptosis in TED patients—transforming care in a previously underserved condition. Ongoing studies are exploring its use in other IGF-1R–mediated conditions.
Required Qualifications:
🧾 Basic Qualifications (one of the following):
Doctorate degree + 6 years of directly related experience, OR
Master’s degree + 10 years of directly related experience, OR
Bachelor’s degree + 12 years of directly related experience
AND
6 years of managerial experience (team/project/program leadership or resource allocation)
Preferred Qualifications:
Advanced degree: MD, PharmD, or PhD
3+ years Medical Affairs experience in Immunology, Ophthalmology, or Pharmacology
5+ years Medical Affairs experience in biotech, pharma, or CRO settings
5+ years experience working with Rare Diseases
Experience collaborating with IDNs, ACOs, and Payers
3+ years of clinical research and/or academic medical practice
Familiarity with US regulatory agencies and Good Clinical Practice (GCP)
Strong understanding of pharmaceutical product development, lifecycle, and commercialization
Leadership Expectations:
Amgen leaders are expected to:
Inspire: Build inclusive and empowering environments
Accelerate: Drive progress over perfection to meet patient needs
Integrate: Connect cross-functional teams to amplify impact
Adapt: Embrace change and deliver clear action
Compensation & Benefits:
Base Salary: $343,334 – $403,728 USD
Additional Compensation:
Annual discretionary bonus
Stock-based long-term incentives
Total Rewards Plan includes:
Medical, dental, and vision insurance (for staff and eligible dependents)
Life and disability insurance
Flexible spending accounts
Retirement and savings plans with company contributions
Generous PTO and company-wide shutdowns
Flexible and remote work options
Career development and continuing education support
Additional Information:
Amgen does not set a firm application deadline—applications will be accepted until the position is filled.
Amgen is an Equal Opportunity Employer: Applicants are considered without regard to race, gender, identity, religion, national origin, veteran or disability status.
Accommodations available for individuals with disabilities during the application or interview process upon request.
How to Apply:
🔗 Visit: careers.amgen.com
📤 Apply for Job ID: R-223832
(You may redact or omit age-identifying information such as date of birth or graduation dates when submitting materials.)
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