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Clinical Research Associate

5+ years
$100K/yr - $135K/yr
12 May 17, 2024
Job Description
Job Type: Full Time Education: B.S. Skills: Causality Assessment, Communication Skills, ICD-10 CM, CPT, HCPCS Coding, ICSR Case Processing, Interpersonal Skill, Labelling Assessment, MedDRA Coding, Narrative Writing, Research & Development, Technical Skill, Triage of ICSRs, WHO DD Coding

Job Title: Clinical Research Associate (CRA) / Senior CRA

Employer: [Company Name]

Location: United States

Employment Type: Full-time

Salary Range: $100,000/yr - $135,000/yr (Exact compensation may vary based on skills, experience, and location)

General Position Overview

The Clinical Research Associate (CRA) / Senior CRA is responsible for assisting with clinical trial management, site management, data review and cleaning, and occasionally leading the planning and development of the study set-up and execution. The role ensures compliance with protocols, ICH/GCP, regulatory requirements, and SOPs/Work Instructions.

Key Accountabilities/Core Job Responsibilities

Study Planning and Conduct:

  • Act as primary contact for vendors, investigational sites, and cross-functional teams, escalating to the study lead as necessary.
  • Support and occasionally lead the development/review of clinical study plans, presentations, and project/study-related documents including contracts/site payments.
  • Assist in the development and design of CRFs, participating in the EDC and IXRS specification process and UAT.
  • Oversee and mentor junior team members.
  • Perform in-house review of clinical data listings for completeness and accuracy, escalating issues as needed.
  • Manage clinical monitoring activities and overall site management, ensuring compliance with GCP and applicable regulations, and tracking site performance metrics.
  • Distribute study newsletters and track/report recruitment updates.
  • Assist in the development, approval, and distribution of study-related documents including CRFs, study protocols, study manuals, and other study tools.
  • Participate in clinical study team meetings.
  • Collaborate with internal cross-functional teams (e.g., Clinical Science, Biometrics, Regulatory Affairs) to ensure effective delivery of assigned project milestones.

Site Monitoring Activities:

  • Ensure compliance with CFR, GCP, and internal SOPs and guidelines.
  • Communicate project progress, challenges, and opportunities regularly to Clinical Leadership.
  • Monitor clinical and laboratory data for accuracy and regulatory compliance, ensuring resolution of data queries.
  • Monitor safety issues and site evaluations, resolving with Clinical Team Leader.
  • Monitor SAE reporting and request follow-up information according to SOP.
  • Review protocol violations with the investigator and take corrective actions.
  • Reconcile drug accountability records and regulatory documents at sites.
  • Provide timely monitoring reports in accordance with SOPs.
  • Assist Data Management in resolving data queries.
  • Ensure availability of study supplies at sites and participate in other tasks as needed.
  • Perform pre-study site qualification visits to evaluate site adequacy.
  • Conduct ongoing monitoring visits to verify subject rights, data accuracy, and compliance.
  • Perform close-out visits and other trial completion activities.
  • Ensure site compliance with study protocols, safety, and investigational product accountability.
  • Assist in query writing and resolution.
  • Provide on-site training for investigators and site personnel.
  • Collaborate with cross-functional teams on safety data evaluation, compliance, and data management.
  • Communicate with clinical study team and sites to ensure adherence to timelines.
  • Organize study files, inventory, and materials.
  • Ensure clinical sites have adequate supplies to conduct the study.
  • Attend and/or perform site initiation visits.
  • Assist with mass communications, newsletters, and study coordinator training as needed.

General:

  • Complete required corporate training on standards, policies, and work instructions.
  • Perform other work-related duties as assigned.

Qualifications:

  • B.S. degree required.
  • 5+ years of CRA experience monitoring clinical trials in biotech, pharmaceutical, or CRO environment (8+ years for Sr. CRA).
  • Experience with trial conduct from start-up through close-out.
  • Working knowledge of ICH GCP and FDA regulations.
  • Ability to work effectively with minimal supervision.
  • Ability to multi-task and manage deliverables across all assigned trials.
  • Strong written and verbal communication skills.
  • Ability to travel frequently.
  • Self-motivated and able to work in a small team environment.

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