Advisor / Sr. Advisor – Peptide Phage Display
Location: San Diego, CA
Job Type: Full-Time | Regular
Job ID: R-92956
Category: Research & Development
About Lilly
Lilly is a global healthcare leader committed to discovering and delivering life-changing medicines. Headquartered in Indianapolis, Indiana, Lilly integrates scientific innovation with compassionate care, aiming to make life better for people worldwide. The company fosters a culture of teamwork, integrity, and patient-first values.
Position Overview
This is a technical lead role within the Peptide Discovery Team in Biotechnology Discovery Research (San Diego).
The Advisor/Sr. Advisor will lead the design, development, and execution of next-generation peptide phage display technologies, particularly focusing on multicyclic peptide scaffolds. The role includes hands-on experimental work, leadership of screening projects, and cross-functional collaboration to advance peptide-based therapeutics.
Key Responsibilities
Platform Development & Execution
Develop and refine a robust multicyclic peptide phage display platform using molecular biology, genetic engineering, and chemistry expertise.
Execute peptide phage display screening workflows to discover and optimize peptide hits for biological targets.
Innovate and implement new methods and technologies for platform enhancement.
Project Leadership & Collaboration
Lead peptide phage display screening projects from concept to hit identification.
Collaborate with cross-disciplinary teams including:
Organic Chemistry
Computational Sciences
Structural Biology
Genetic Medicines
Drug Disposition
Bioproduct Development
Regulatory Affairs
Peptide Optimization
Improve peptide properties such as:
Binding affinity
Physicochemical attributes
Pharmaceutical developability
Partner with peptide chemists to apply rational SAR (Structure–Activity Relationship) strategies.
Validate peptide actives from selection campaigns and support biochemical/cellular assay development.
Team Leadership
Mentor and train junior scientists in:
Phage display platform build
Experimental execution
Troubleshooting and problem-solving
Required Qualifications
Ph.D. in Chemistry, Biochemistry, or Molecular Biology, focusing on peptide science.
Minimum 2+ years industry experience (biotech/pharma) with:
Demonstrated leadership in peptide discovery
Track record of advancing peptide therapeutics from concept to development
Preferred Skills & Experience
Experience supervising or mentoring junior scientists.
Publications or patents demonstrating expertise in state-of-the-art peptide phage display platforms.
Experience designing biochemical and cell-based assays for peptide discovery.
Strong understanding of:
Physicochemical and ADME properties
Compound modeling and measurements
Peptide formulation considerations
Ability to evaluate, triage, and validate peptide leads.
Strong cross-functional teamwork, communication, organizational, and presentation skills.
Competencies & Attributes
Strong problem-solving abilities.
Deep understanding of challenges in:
Peptide discovery
Peptide engineering
Pharmaceutical developability
Biology and formulation
Ability to work independently and collaboratively in multidisciplinary teams.
Compensation & Benefits
Salary Range: $133,500 – $217,800 (based on experience, education, and location).
Eligible for:
Annual company bonus
401(k) and pension
Medical, dental, vision, and prescription benefits
Life insurance
Flexible spending accounts
Paid vacation and leave programs
Well-being resources (EAP, fitness benefits, clubs, etc.)
Equal Opportunity & Inclusion
Lilly is an Equal Opportunity Employer. The company does not discriminate based on age, race, gender identity, sexual orientation, national origin, disability, veteran status, or other protected characteristics.
Employee resource groups (ERGs) include networks for:
Black Employees
Latinx Employees (OLA)
PRIDE (LGBTQ+ Allies)
Women Leaders (WILL)
Veterans (VLN)
Disability Support (enAble)
Asian, Indian, Chinese, and Japanese cultural networks
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