Job Title: Team Lead – Assay Biologist
Location: Bangalore, Karnataka, India
Division: Discovery Services
Department: Discovery Biology
Syngene International Ltd., established in 1993, is a global contract research, development, and manufacturing organization delivering integrated scientific services from early discovery to commercial supply. Our expertise spans pharmaceuticals, biotechnology, nutrition, animal health, consumer goods, and specialty chemicals. Syngene’s 4,240+ scientists work with world-leading clients such as Bristol-Myers Squibb, Amgen, Baxter, GSK, Merck KGaA, and Herbalife, driving innovation, R&D productivity, and faster time-to-market solutions.
The Team Lead – Assay Biologist will lead a team of scientists in the Assay Development Group, overseeing the development and qualification of cell-free biochemical and biophysical assays. The role involves client interfacing, project management, assay development, troubleshooting, and data analysis while ensuring compliance with quality, regulatory, and EHS standards.
Lead and manage a team of scientists, including goal setting, mentoring, task assignment, and performance evaluation.
Drive the scientific execution of cell-free and biochemical assays, troubleshoot experiments, and ensure accurate data interpretation.
Lead client-facing projects, providing regular updates and transparent communication on project progress.
Develop, qualify, and execute high-throughput assays using multiple formats: HTRF, FP, TR-FRET, AlphaLISA, Luminescence, HiBiT, qPCR, and label-free technologies.
Conduct Mechanism of Action (MoA) determination assays for small molecules, including enzyme inhibition, protein-protein interactions, and ternary complexes.
Oversee assay screening for primary and secondary compound evaluations to support Structure-Activity Relationship (SAR) studies.
Maintain compliance with EHS protocols, biosafety guidelines, and company policies.
Review and approve electronic laboratory notebooks, raw data, and study reports to ensure data integrity.
Present technical data effectively using Excel, PowerPoint, GraphPad Prism, and statistical tools.
Collaborate with cross-functional teams to develop innovative assay platforms and improve laboratory practices.
Ph.D. or Master’s degree in Biological Sciences or related fields.
Expertise in assay development and validation for biochemical and cell-based formats.
Strong understanding of high-throughput screening, assay miniaturization (96-, 384-, 1536-well formats), and automation.
Proficiency with multi-mode readers, liquid handlers, and laboratory automation systems.
Experience in compound screening, SAR analysis, and QC parameters for assay performance.
Knowledge of regulatory guidelines related to biosafety and statistical data analysis.
Strong team management, mentoring, and coaching capabilities.
Excellent verbal and written communication skills for client and team interactions.
Ability to work collaboratively across departments and external partners with professionalism.
Effective planning, prioritization, and time-management skills to deliver quality results on schedule.
Proven experience in leading assay development teams and delivering results in a drug discovery or related research environment.
Hands-on experience with cell-free biochemical and biophysical assay development.
Opportunity to lead a high-impact team working on cutting-edge drug discovery assays.
Exposure to global clients and innovative research projects.
Work in a collaborative, safety-conscious, and innovation-driven environment.
Syngene provides equal employment opportunities (EEO) to all individuals regardless of age, gender, disability, nationality, religion, sexual orientation, or other legally protected characteristics. Reasonable accommodations are provided for qualified individuals with disabilities.
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