Senior Scientist I / Senior Scientist II – Neuroscience (Synaptic & Cellular Neurobiology Unit)
Job ID: REQ-10066840
Location: Cambridge, MA (Onsite)
Division: Biomedical Research
Business Unit: Research
Functional Area: Research & Development
Employment Type: Full-Time, Regular
Shift: No Shift Work
Date Posted: Nov 12, 2025
#LI-Onsite
🔹 Summary
Novartis Biomedical Research is seeking a creative and collaborative Senior Scientist (SS1 or SS2 level depending on experience) to join the Synaptic & Cellular Neurobiology Unit within the Neuroscience research department. The role involves designing, executing, and delivering preclinical research data using in vitro cellular models and in vivo animal models, supporting innovative drug discovery for neurological disorders.
🔹 About the Role
This position can be filled at:
Senior Scientist I (SS1)
OR
Senior Scientist II (SS2) — based on expertise and experience.
The scientist will work in a matrixed, collaborative setting with teams across Neuroscience and Biomedical Research.
🔹 Key Responsibilities
Experimental Design & Execution
Plan, design, conduct, and analyze experiments to address key scientific questions.
Use in vitro and in vivo models to generate decision-making datasets for drug discovery programs.
In Vitro Research
Implement and optimize techniques such as:
Mouse & human neuronal cell culture
Immunocytochemistry
Fluorescence imaging & image analysis
Biochemical assays (Western blot, ELISA, MSD, JESS)
Gene expression tools (RT-qPCR)
In Vivo Research
Perform and analyze rodent model experiments including:
Dosing
Tissue collection
Ex vivo analysis
Conduct CNS delivery procedures:
Intracranial injections
Intracerebroventricular injections
Execute peripheral delivery routes:
IV, Retro-orbital, IP
Perform advanced necropsy and dissections (brain/spinal cord extraction, CSF collection).
Data Management & Reporting
Keep electronic lab notebooks updated.
Summarize, interpret, and present research findings to project teams.
SS2 Level Additional Expectations
Propose novel experiments.
Contribute to shaping preclinical strategies.
Act as an emerging scientific leader.
🔹 Essential Requirements
Education
B.S. degree in neuroscience, cell biology, or related discipline.
Experience
Senior Scientist I (SS1): ≥ 4 years relevant lab-based neuroscience experience.
Senior Scientist II (SS2): ≥ 7 years relevant experience.
Technical Expertise
Strong experience with:
Rodent primary neuronal culture
Cell-based assays
Immunocytochemistry
Fluorescence microscopy
Image analysis & statistical analysis
Gene (RT-qPCR) and protein expression assays
Proficiency with in vivo rodent work including:
Stereotaxic brain surgery
CNS/peripheral dosing
Tissue & CSF collection
Soft Skills
Proactive, self-motivated, organized, and able to multitask.
Ability to work independently and in collaborative matrix teams.
🔹 Preferred Qualifications
M.S. degree in relevant field.
Industrial research experience (≥50% of total experience preferred).
Experience with embryonic rodent brain dissection and neuronal dissociation.
🔹 Compensation
Salary Ranges
Senior Scientist I: $85,000 – $158,000 per year
Senior Scientist II: $93,000 – $174,000 per year
Final salary depends on:
Skills
Experience
Market factors
Internal evaluation
Additional Compensation
Performance-based cash incentive
Potential eligibility for annual equity awards
Benefits
Health, life, disability insurance
401(k) with company contribution + match
Generous paid time off: vacation, personal days, holidays
Additional leaves as per company policy
🔹 Why Novartis?
Novartis fosters a culture of innovation, collaboration, and scientific excellence. The work you do directly impacts patients and families worldwide. Join a passionate community making breakthroughs in medicine.
🔹 Accessibility
Reasonable accommodations for individuals with disabilities are available during the application process.
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