Job Title: Senior Research Investigator / Principal Investigator – Drug Discovery Services (DDS)
Location: Bangalore, Karnataka, India
Department: Drug Discovery Services (DDS)
Company: Syngene International Ltd.
Experience Required: 5–10 years of relevant industrial research experience after PhD/Post-Doctoral research
About Syngene International Ltd.
Syngene International Ltd., founded in 1993, is a globally recognized contract research, development, and manufacturing organization (CRDMO). The company delivers integrated scientific solutions spanning drug discovery, development, and manufacturing for pharmaceutical, biotechnology, nutrition, animal health, consumer goods, and specialty chemical industries worldwide.
Syngene collaborates with leading global organizations including Bristol-Myers Squibb, Baxter, Amgen, GSK, Merck KGaA, and Herbalife. With a strong focus on innovation and scientific excellence, the company works closely with international clients to address complex research challenges, enhance R&D productivity, accelerate drug development timelines, and optimize innovation costs.
Role Overview
The Senior Research Investigator / Principal Investigator will play a critical role in the Drug Discovery Services (DDS) division by leading scientific research activities and supporting project execution in medicinal and synthetic chemistry programs. The position involves performing and supervising complex organic synthesis reactions, maintaining data integrity through ALCOA+ documentation principles, and ensuring timely delivery of research milestones.
The role also includes mentoring junior scientists, managing project resources, collaborating with cross-functional teams, and maintaining strict compliance with environmental health and safety (EHS) standards within the laboratory environment.
Key Responsibilities
Project Execution and Scientific Research
Perform and supervise organic synthesis reactions while adhering to established laboratory safety protocols.
Maintain accurate and compliant scientific documentation in laboratory notebooks or electronic lab notebooks in accordance with ALCOA+ data integrity principles.
Execute experimental work independently or collaboratively within multidisciplinary teams.
Troubleshoot experimental challenges and implement scientifically sound solutions to ensure research continuity.
Project Management and Reporting
Plan and manage research projects to ensure timely completion of assigned milestones and deliverables.
Provide regular technical updates and detailed progress reports to internal stakeholders and external clients.
Ensure efficient utilization of laboratory resources and maintain cost-effective project execution.
Coordinate with team members to align project objectives with client expectations and timelines.
Team Leadership and Mentorship
Supervise research associates and junior scientists to support timely and high-quality project completion.
Mentor junior team members and contribute to their technical skill development.
Foster collaboration across interdisciplinary teams including medicinal chemistry, biology, and DMPK scientists.
Laboratory Operations and Safety Compliance
Ensure compliance with environmental, health, and safety (EHS) guidelines across all laboratory activities.
Maintain proper handling, storage, and documentation of chemicals in accordance with Safety Data Sheets (SDS).
Ensure laboratory instruments and equipment are used correctly, maintained properly, and cleaned after use.
Report equipment malfunctions or operational issues promptly to maintenance teams.
Ensure safe waste disposal and adherence to laboratory safety protocols.
Additional Responsibilities
Conduct scientific literature searches using research databases such as SciFinder or Reaxys.
Maintain strict confidentiality of research data and client information.
Participate in mandatory compliance and safety training programs.
Perform additional laboratory and research-related tasks assigned by the supervisor or group leader.
Educational Qualifications
PhD in Chemistry or a closely related scientific discipline.
Post-doctoral research experience is preferred.
Technical Skills and Expertise
Strong understanding of organic chemistry reactions and analytical characterization techniques.
Expertise in computational chemistry and structure-based drug discovery approaches.
Knowledge of molecular mechanics and quantum mechanics concepts.
Experience with computational tools including molecular docking, pharmacophore modeling, molecular dynamics simulations, and quantum mechanical calculations.
Proficiency in statistical analysis methods used in scientific research.
Strong knowledge of physical organic chemistry principles.
Programming proficiency in Python and/or Unix shell scripting.
Familiarity with scientific tools such as ChemDraw and Microsoft Office applications.
Experience working within interdisciplinary research teams including medicinal chemistry, biology, and DMPK groups.
Exposure to therapeutic areas such as oncology, immunology, cardiovascular diseases, or fibrosis is considered an advantage.
Professional and Behavioral Competencies
Strong communication, presentation, and scientific documentation skills.
Ability to collaborate effectively in cross-functional research environments.
Strong analytical thinking and problem-solving capabilities.
Ability to manage multiple projects and meet tight deadlines.
Demonstrated leadership and mentoring skills.
High attention to detail and commitment to scientific excellence.
Workplace Safety and Compliance
Employees are expected to follow Syngene’s established safety culture by adhering to regulatory standards, laboratory safety protocols, and operational procedures. Completion of mandatory training related to data integrity, health and safety, and compliance requirements is essential.
Equal Opportunity Employer
Syngene International Ltd. is committed to maintaining an inclusive and diverse workplace. The company provides equal employment opportunities to all qualified applicants regardless of race, color, religion, gender, sexual orientation, gender identity, national origin, disability status, veteran status, or any other protected characteristic under applicable laws. Reasonable accommodations are available for qualified individuals with disabilities.
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