Principal Site Grant Manager
Updated: December 28, 2025
Location: United States – Morrisville, NC (Hybrid)
Open to: US Remote Candidates
Job ID: 25104681
Employment Type: Full-Time
Company Overview
Syneos Health® is a global, fully integrated biopharmaceutical solutions organization dedicated to accelerating customer success across the clinical development lifecycle. With operations spanning more than 110 countries and a workforce of over 29,000 professionals, Syneos Health delivers innovative clinical, medical affairs, and commercial solutions that help bring therapies to patients faster.
Driven by a patient-centric Clinical Development model, Syneos Health continuously improves efficiency, quality, and collaboration to support sponsors in navigating modern clinical research and regulatory landscapes.
Role Overview
Syneos Health is seeking an experienced Principal Site Grant Manager to provide strategic leadership in investigator budget development, Fair Market Value (FMV) assessment, and global site grant management. This senior-level role serves as a subject matter expert for site budgeting and contracting strategies, supporting complex clinical trial programs across multiple regions.
The Principal Site Grant Manager will collaborate closely with sponsors, clinical operations, legal, finance, and site start-up teams to ensure investigator grant budgets are compliant, competitive, and aligned with operational and regulatory requirements.
Key Responsibilities
Strategic Site Grant & Budget Leadership
Lead the development, maintenance, and governance of investigator budget templates, country-specific grant estimates, and negotiation parameters in alignment with sponsor and company requirements.
Serve as the primary subject matter expert and internal escalation point for global site grant budgeting and FMV-related issues.
Establish and update training materials for investigator budget teams and site contract negotiators.
Actively contribute to higher-level discussions related to business unit goals, project strategies, and operational objectives.
Investigator Budget Development & FMV
Develop and update detailed investigator grant budgets and country-level templates based on protocol requirements and amendments using approved budgeting tools and systems.
Ensure budgets reflect Fair Market Value principles, operational complexity, protocol demands, and integrated site activation plans.
Validate investigator grant estimates using internal benchmarks and external industry data.
Identify budget-related risks and proactively propose mitigation strategies to ensure timely site activation and study execution.
Cross-Functional & Sponsor Collaboration
Partner with sponsors to harmonize investigator budget templates, payment terms, and negotiation strategies across global programs.
Collaborate with internal legal, finance, clinical operations, and quality assurance teams to address budgetary, contractual, and compliance issues.
Establish strong working relationships with internal project teams and external customers to support program-level objectives.
Process Improvement & Governance
Identify best practices and lead continuous improvement initiatives to enhance efficiency, quality, and scalability of site grant management processes.
Escalate deviations and compliance concerns to senior management and support resolution in collaboration with Quality Assurance.
Create and maintain accurate documentation, budget status reports, and departmental tracking tools.
Leadership, Training & Representation
Train, mentor, and support less experienced team members on SOPs, tools, templates, and site grant management processes.
Represent Syneos Health at professional meetings, seminars, and business development presentations as a subject matter expert in site budgeting and FMV.
Support internal help desk activities, process improvement initiatives, and organizational training programs as required.
Perform additional duties aligned with business needs; limited travel may be required (up to 25%).
Required Qualifications & Experience
Bachelor’s degree in life sciences, healthcare, or a related discipline; equivalent education and experience will be considered.
Minimum 8–10 years of experience within the CRO or pharmaceutical industry, with strong exposure to clinical trial operations, site start-up, or investigator grant management.
Demonstrated expertise in investigator budget development, FMV analysis, site grant negotiations, and clinical trial cost benchmarking.
Prior experience in roles such as Study Coordinator, CRA, Site Start-Up Specialist, Pharmacy, Nursing, or Healthcare Administration is highly desirable.
Thorough knowledge of global clinical trial regulations, drug development processes, and clinical project management practices.
Strong leadership, mentoring, and coaching capabilities with experience guiding teams toward performance objectives.
Excellent written and verbal communication, documentation, and presentation skills.
High attention to detail with the ability to manage multiple priorities in a fast-paced, matrix-driven environment.
Proficiency in Microsoft Word, Excel, PowerPoint, MS Project, Outlook, and internet-based collaboration tools.
Compensation & Benefits
Salary Range: USD 79,800 – 139,600 (base salary)
Comprehensive benefits package including medical, dental, and vision coverage
401(k) with company match
Employee Stock Purchase Plan eligibility
Performance-based bonus and incentive opportunities
Flexible paid time off (PTO) and sick leave in compliance with federal, state, and local regulations
Company car or car allowance may be applicable based on role requirements
Final compensation will be determined based on experience, skills, location, and business needs.
Why Join Syneos Health
Contribute to clinical programs supporting 94% of novel FDA-approved drugs and 95% of EMA-authorized products in the past five years.
Work within a globally inclusive, diverse, and collaborative organization.
Gain exposure to high-impact global clinical research programs and strategic sponsor partnerships.
Access ongoing professional development, leadership growth, and career advancement opportunities.
Apply Now
Apply through thepharmadaily.com to explore this senior-level Principal Site Grant Management opportunity with a global biopharmaceutical leader.
Not ready to apply? Join the Talent Network to stay informed about future Site Start-Up, Clinical Operations, and Grant Management roles worldwide.
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