Job Title
Principal Scientist, Preclinical Safety & Translational Sciences – Translational Pharmacokinetics/Pharmacodynamics
Company
Johnson & Johnson
Locations
Spring House, Pennsylvania, United States of America
San Diego, California, United States of America
Work Pattern
Hybrid Work
Job Function
Discovery & Pre-Clinical/Clinical Development
Job Sub-Function
Pharmacokinetics & Pharmacometrics
Job Category
Principal Scientist, Pharmacokinetics & Pharmacometrics (ST7)
Requisition Number
R-018751
Date Posted
August 29, 2025
Application Deadline
September 30, 2025 (may be extended)
Company Overview
Johnson & Johnson is a leader in healthcare innovation, developing advanced medicines and medical technologies that save and improve lives. Their Innovative Medicine sector focuses on translating patient insights into breakthrough treatments. Learn more at jnj.com/innovative-medicine.
Position Purpose
The Principal Scientist will be an integral member of discovery project teams, collaborating closely with biology, chemistry, and drug metabolism/pharmacokinetics (DMPK) colleagues. The role focuses on designing and applying quantitative model-based analyses—including physiologically-based pharmacokinetic (PBPK) modeling, mechanistic PK/PD modeling, and systems pharmacology—to guide candidate selection, dosing recommendations, and experimental design for preclinical and early clinical studies.
Key Responsibilities
Apply PK/PD modeling to inform decision-making from early discovery through early clinical development.
Develop and guide modeling and simulation strategies within the organization.
Collaborate cross-functionally to predict pharmacokinetic profiles and quantify exposure-response relationships for biomarkers, efficacy, and safety.
Design and optimize in vivo and in vitro experiments to support modeling efforts.
Qualifications
Education
PhD in Pharmacology, Engineering, Mathematics, Physics, or related field with at least 4 years relevant industry experience, OR
Master’s degree with at least 6 years relevant industry experience.
Experience & Skills
Strong knowledge of pharmacokinetics and pharmacodynamics principles.
Experience performing PK and/or PK/PD modeling preferred.
Proven expertise in mathematical modeling and simulation (peer-reviewed publications a plus).
Excellent interpersonal, organizational, verbal, and written communication skills.
Team-oriented and able to work collaboratively across disciplines.
Other
Position may require up to 10% travel.
Compensation
Base salary range: $115,000 – $197,800
Eligible for annual performance-based cash bonus (discretionary).
Benefits
Medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance.
Retirement plans including pension and 401(k).
Paid time off including vacation (up to 120 hours/year), sick leave (up to 40 hours/year; 56 hours in Washington state), holidays (up to 13 days/year), and personal/family time (up to 40 hours/year).
More information: Johnson & Johnson Employee Benefits
Equal Employment Opportunity
Johnson & Johnson is an Equal Opportunity Employer committed to diversity and inclusion. All qualified applicants will receive consideration regardless of race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status, or other protected characteristics. Accommodations are available upon request.
For accommodation requests, contact:
Employee Health Support Center – ra-employeehealthsup@its.jnj.com
AskGS – accommodation resource
Job Posting Notes
This posting may remain open beyond the listed close date to accept additional applications.
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