Principal Scientist I – Imaging Expert, Clinical Imaging & Analytics
Location: Cambridge, MA, USA | Company: Novartis Institutes for BioMedical Research
Work Mode: Hybrid | Job Type: Full-time | Employment Type: Regular
Job Summary
Novartis is seeking a Principal Scientist I – Imaging Expert to join its Biomarker Development team at the Cambridge, MA site. In this key position, you'll serve as a scientific and technical lead in PET and SPECT imaging, driving translational imaging strategies and supporting preclinical to clinical drug development programs. This role offers unique cross-therapeutic exposure and collaborative engagement with research and clinical teams to design impactful imaging endpoints and accelerate innovation in healthcare.
Key Responsibilities
Serve as the internal subject matter expert in PET and SPECT imaging across preclinical and clinical programs.
Develop and implement fit-for-purpose imaging strategies for clinical trials.
Collaborate with internal teams and imaging CROs to execute trial imaging components.
Ensure data quality and responsiveness during trial execution and interpretation.
Identify and apply novel imaging modalities and endpoints in clinical protocols.
Lead imaging readouts to evaluate eligibility, efficacy, safety, and mechanisms of action.
Engage with external key opinion leaders (KOLs) to refine imaging strategies.
Drive radioligand development and molecular imaging from late preclinical through clinical transition.
Partner with translational science teams to design integrated biomarker strategies.
Required Skills & Qualifications
PhD, MD, or MD/PhD with experience in PET/SPECT imaging in academic, industry, or CRO settings.
Deep technical knowledge of PET/SPECT imaging for in-life (preclinical/clinical) applications.
Experience with Radioligand Therapy (RLT/RPT) and radiochemistry is a plus.
Familiarity with regulatory submissions, dosimetry, receptor occupancy, and FIH protocols.
Understanding of clinical trial design, endpoint statistics, and data flow.
Proven ability to work cross-functionally in matrixed R&D environments.
Self-motivated, results-oriented, and accountable with a strong collaborative mindset.
Excellent communication skills and fluency in English.
Perks & Benefits
Salary Range: $103,600 – $192,400/year
Performance-based cash incentives and equity award eligibility
Comprehensive medical, life, and disability insurance
401(k) plan with company contribution and matching
Generous paid time off including vacation, personal days, and parental leave
Career development resources and training programs
Company Description
Novartis Institutes for BioMedical Research (NIBR) is a global leader in translational research and drug discovery, focused on developing next-generation therapeutics in oncology, immunology, neuroscience, and more. NIBR's mission is to reimagine medicine and improve lives through breakthrough science and data-driven innovation.
Work Mode
Hybrid – Combination of on-site and flexible work from Cambridge, MA.
Call-to-Action
Are you passionate about advancing translational imaging and accelerating novel therapies? Join Novartis and make a global impact in healthcare innovation. Apply now to become a Principal Scientist I in Clinical Imaging & Analytics.
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