Principal Scientist II – Imaging Expert, Clinical Imaging & Analytics
Location: Cambridge, MA | Company: Novartis Institutes for BioMedical Research
Work Mode: Hybrid | Job Type: Full-time | Employment Type: Regular
Job Summary
Novartis is seeking a Principal Scientist II – Imaging Expert to join its Clinical Imaging & Analytics team in Cambridge, Massachusetts. In this pivotal role within the Biomarker Development group, you will lead innovative imaging strategies and apply PET/SPECT expertise to drive clinical and translational research across multiple therapeutic areas. This is a high-impact opportunity to influence early drug development using molecular imaging endpoints.
Key Responsibilities
Serve as internal expert in PET and/or SPECT imaging for clinical trials.
Lead exploratory imaging analysis to uncover safety, efficacy, and biomarker insights.
Develop and implement novel imaging endpoints to support clinical development.
Partner with senior imaging experts and collaborate with imaging CROs.
Integrate imaging strategies into trial design, patient selection, and mechanistic understanding.
Ensure high-quality execution of imaging components in clinical trials.
Work cross-functionally with Research, Translational Science, and Clinical Operations teams.
Manage external academic and CRO relationships to advance imaging science.
Required Skills & Qualifications
PhD, MD, or MD/PhD with 3+ years of PET/SPECT imaging experience in academia, pharma, or CRO.
Deep understanding of clinical trial imaging, including hands-on data analysis.
Demonstrated innovation in imaging modalities and biomarker development.
Experience in radioligand/radiopharmaceutical therapy (RLT/RPT) is a plus.
Knowledge of regulatory submission processes and first-in-human imaging protocols.
Familiarity with dosimetry, receptor occupancy, and clinical trial design.
Strong project management and communication skills; ability to work in matrixed teams.
Proactive, self-motivated, with a drive for scientific excellence and translational impact.
Perks & Benefits
Salary Range: $114,100 – $211,900/year
Performance-based cash incentives and equity awards
Comprehensive health, life, and disability insurance
401(k) plan with company match
Generous PTO including vacation, personal days, and parental leave
Opportunities for continuous learning and internal advancement
Company Description
Novartis Institutes for BioMedical Research (NIBR) is a global leader in translational science, pioneering discoveries in oncology, immunology, neuroscience, and beyond. Our mission is to bring transformative medicines to patients through cutting-edge research, world-class science, and a culture of collaboration and innovation.
Work Mode
Hybrid – On-site presence in Cambridge, MA required
Call-to-Action
Ready to lead next-generation clinical imaging innovations at one of the world’s leading pharmaceutical companies? Apply now to become a Principal Scientist II at Novartis and contribute to breakthroughs that transform patient care.
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