Job Title: Director, Quantitative Pharmacology and Pharmacometrics – Immune/Oncology (Remote)
Company: Merck & Co.
Location: Remote (U.S.-based, not within commuting distance to primary sites)
Posting City: San Francisco, CA
Job Code: MERCUSR332888ENUS_9DNP36HHKOrj
Category: IT (though functionally in Clinical Pharmacology / Pharmacometrics)
Type: Full-time
Post Date: May 2, 2025
Team
Department: Quantitative Pharmacology and Pharmacometrics (QP2) – Immune/Oncology
Part of: Global Clinical Development organization
Key Responsibilities
Serve as subject matter expert in pharmacometrics for oncology development programs
Lead model-based drug development strategies including:
Translational PK/PD modeling
Population PK modeling
Exposure-response analysis
Tumor size and survival modeling
QSP (Quantitative Systems Pharmacology) modeling
Author regulatory documents (INDs, CTDs, CSRs) and represent QP2-IO in meetings with global health authorities
Mentor/supervise junior scientists
Collaborate cross-functionally with internal teams and external vendors
Education Requirements
Ph.D. with 7+ years of relevant experience
OR Master’s/PharmD with 9+ years of experience
Relevant fields: Pharmacokinetics, Pharmacology, Pharmacometrics, Biostatistics, Engineering, or related life sciences
Required Experience & Skills
Proven leadership in model-informed drug development
Strong record of regulatory submission support (IND, NDA, etc.)
High proficiency in modeling tools: NONMEM, R, MATLAB, Monolix
Strong statistical and data interpretation skills
Exceptional written and verbal communication
Remote Work Eligibility
Role is remote only for applicants outside commuting distance to Merck's primary sites
Candidates near office sites should apply to requisition R332890 for hybrid work model
Compensation & Benefits
Salary Range: $187,000 – $294,400
Includes:
Bonus eligibility
Long-term incentive program (if applicable)
Medical, dental, vision insurance
Retirement benefits
Paid time off, sick leave, holidays
Equal Opportunity & Legal Compliance
Merck is an Equal Employment Opportunity employer
Complies with EEOC, ADA, San Francisco Fair Chance Ordinance, and Los Angeles Fair Chance Initiative
Supports inclusive, diverse, and respectful work environments
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