Clinical Genomics Variant Scientist
Job ID: 27905
Employment Type: Full-Time, Permanent (Staff – Career)
Location: Los Angeles, California, United States
Work Schedule: Monday to Friday | 8:00 AM – 5:00 PM
Salary Range: USD 105,700 – 234,500 per annum
Posted Date: December 29, 2025
Organization: UCLA Health
Function: Molecular Diagnostics | Clinical Genomics | Precision Medicine
Role Overview
UCLA Health is seeking a highly skilled Clinical Genomics Variant Scientist to join its Molecular Diagnostics Laboratory. This role plays a critical part in precision medicine by curating, interpreting, and reporting germline and somatic genomic variants derived from high-complexity sequencing assays.
The position supports clinical diagnostics, test development, and translational research initiatives, working closely with clinicians, genetic counselors, and laboratory professionals to deliver accurate and clinically meaningful genomic insights.
Key Responsibilities
Review and interpret patient clinical information and next-generation sequencing (NGS) data from high-complexity assays, including:
Clinical Exome Sequencing
Solid Tumor Sequencing Panels
Hematologic Malignancy Sequencing Panels
Perform variant curation and classification using established guidelines (e.g., ACMG/AMP, AMP/ASCO/CAP) and evidence-based genomic resources
Prepare, review, and finalize high-quality clinical genomics reports, ensuring clarity, accuracy, and clinical relevance
Develop, maintain, and update standard operating procedures (SOPs) related to variant interpretation, classification, and reclassification workflows
Submit curated variants to public genomic databases such as ClinVar in compliance with best practices
Collaborate cross-functionally with molecular pathologists, genetic counselors, clinicians, and laboratory teams
Support test development, assay validation, quality improvement initiatives, and implementation of new molecular diagnostics
Contribute to clinical research projects aligned with precision medicine and translational genomics
Required Qualifications and Experience
Education
Master’s or Doctoral degree (MS, PhD, MD, or equivalent) in Genetics, Genomics, Molecular Biology, Bioinformatics, or a related life sciences discipline
Experience
Minimum 3–7 years of relevant experience in clinical genomics, molecular diagnostics, or variant interpretation within a clinical or CLIA-certified laboratory environment
Demonstrated experience interpreting germline and/or somatic variants from NGS-based assays
Experience with clinical reporting and variant classification frameworks
Key Skills and Competencies
Strong expertise in variant curation, interpretation, and clinical genomics reporting
Working knowledge of NGS technologies, cancer genomics, and inherited disease genomics
Familiarity with genomic databases and tools such as ClinVar, gnomAD, COSMIC, OMIM, and PubMed
Excellent scientific writing, documentation, and communication skills
Ability to work effectively in multidisciplinary clinical and research teams
High attention to detail, quality, and regulatory compliance
Understanding of laboratory quality standards, validation processes, and continuous improvement
Why Join UCLA Health
UCLA Health is a globally recognized leader in healthcare, research, and academic medicine. Joining the Molecular Diagnostics Laboratory offers the opportunity to work at the forefront of genomic medicine, contribute to impactful clinical care, and collaborate with experts shaping the future of precision diagnostics.
SEO & GPT Optimization Keywords:
Clinical Genomics Scientist, Variant Scientist Jobs, Molecular Diagnostics Careers, NGS Variant Interpretation, Precision Medicine Jobs USA, Clinical Genomics Los Angeles, Somatic and Germline Variant Scientist, Genomic Data Interpretation
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