Advisor - ADME Project Leadership
Location: Indianapolis, Indiana, United States
Category: Research & Development
Job Type: Full Time, Regular
Job ID: R-80208
Company Overview:
Lilly is a global healthcare leader headquartered in Indianapolis, Indiana, committed to discovering life-changing medicines and improving disease management worldwide. Employees work to enhance patient outcomes through scientific innovation, philanthropy, and volunteerism.
Compensation:
Actual compensation depends on education, experience, skills, and geographic location.
Anticipated Salary: $142,500 - $228,800
Role Overview:
The ADME Project Leadership Advisor will play a key technical leadership role across multidisciplinary teams to deliver novel therapies, including small molecules, biologics, peptides, ADCs, siRNAs, gene therapies, and other complex modalities. The advisor will be responsible for experimental design, data interpretation, and contributing to the discovery and clinical development of investigational targets.
Key Responsibilities:
Lead ADME (Absorption, Distribution, Metabolism, and Excretion) studies to support preclinical and clinical development of Lilly’s diverse portfolio.
Design and implement hypothesis-driven studies to address ADME, PK/PD, and clinical pharmacology questions.
Deliver integrated data packages to guide compound selection, study design, portfolio decisions, and regulatory submissions.
Collaborate with cross-functional teams, including Toxicology, Pharmacology, Chemistry, Clinical PK/PD, Clinical Pharmacology, Regulatory, and Medical, to assess drugability and optimize ADME properties.
Use in vitro, in vivo, and in silico data to define structure-activity and structure-property relationships to optimize drug candidates.
Prepare regulatory communications and documents supporting clinical development, NDAs, BLAs, and line extensions.
Mentor and coach fellow scientists while fostering collaborative team behaviors.
Basic Qualifications:
Ph.D. in Biochemistry, Biology, Cell Biology, Pharmacokinetics, Pharmacology, or related scientific fields.
0-5 years of relevant experience.
Preferred Skills and Experience:
PK/PD modeling and/or biodistribution experience.
Experience in drug discovery and development across therapeutic areas.
Proficiency in PCR, immunoassay, and LC/MS bioanalytical methodology.
Strong knowledge of pharmacokinetics, ADME, and drug interactions.
Ability to balance multiple projects and responsibilities effectively.
Strong written and verbal communication skills, with the ability to integrate diverse perspectives.
Experience with modeling software (e.g., SimCYP, GastroPlus, NONMEM, Matlab).
Experience authoring regulatory and technical reports.
Equal Employment Opportunity:
Lilly is an EEO/Affirmative Action Employer that promotes diversity and does not discriminate based on age, race, religion, gender, sexual orientation, or any other protected status.
Benefits:
Eligible employees receive competitive benefits, including:
Company-sponsored 401(k) and pension plans.
Medical, dental, vision, and prescription drug benefits.
Flexible spending accounts.
Life insurance and death benefits.
Paid time off and leave of absence benefits.
Employee assistance programs, fitness benefits, and employee clubs.
Accommodation:
Lilly provides accommodations for individuals with disabilities during the application process. Requests can be submitted through Lilly’s Accommodation Request Form.
#WeAreLilly
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