Staff Scientist I, LC-MS/MS
Company: Labcorp
Location: Indianapolis, Indiana, USA
Job ID: 2618563
Category: Clinical
Job Type: Full-Time
Work Schedule: Monday–Friday (Day Shift)
Remote: No
Role Overview
The Staff Scientist I, LC-MS/MS will be responsible for developing, validating, and optimizing LC-MS/MS methods for small and large molecules in biological matrices. The role requires advanced scientific expertise, troubleshooting capabilities, technical leadership, client interaction, and support for laboratory operations in a regulated clinical environment.
Key Responsibilities
LC-MS/MS Method Development & Validation
Develop and validate LC-MS/MS methods for:
Small molecules (e.g., steroids, vitamins)
Large molecules (e.g., proteins, antibody-drug conjugates)
Design and optimize sample preparation techniques:
Protein precipitation
Solid Phase Extraction (SPE)
Liquid-Liquid Extraction (LLE)
Supported Liquid Extraction (SLE)
Derivatization
Digestion workflows
Develop semi-quantitative and quantitative analytical methods.
Scientific Leadership & Troubleshooting
Perform advanced troubleshooting of assays and instrumentation.
Lead scientific initiatives to resolve complex analytical challenges.
Apply and interpret scientific theories, analytical techniques, and regulatory requirements.
Provide scientific consultation to laboratory and operational teams.
Contribute to departmental technical policies and long-term planning.
Technical Support & Collaboration
Support monitoring and evaluation of clinical assays.
Provide technical training to laboratory personnel.
Consult with cross-functional teams such as Project Management.
Assist in managing scientific vendor relationships.
Participate in client visits and scientific discussions.
Research & Scientific Communication
Stay current with scientific literature and emerging technologies.
Prepare scientific reports, publications, and presentations.
Present scientific findings to clients and professional groups.
Attend conferences, seminars, and industry meetings.
Compliance & Quality
Ensure compliance with:
CAP
CLIA
Applicable regulatory requirements
Maintain scientific and operational quality standards.
Minimum Qualifications
Bachelor's Degree in a relevant scientific field.
5+ years of relevant laboratory experience.
Strong hands-on experience with LC-MS/MS platforms, including:
Sciex 6500+
Waters Acquity UPLC
Proven experience in LC-MS/MS method development and validation.
Experience with analytical software:
Sciex Analyst
Sciex MultiQuant
Indigo Ascent
Strong research, data interpretation, and technical report writing skills.
Experience preparing scientific publications and presentations.
Knowledge of:
Clinical laboratory automation
Laboratory statistics
Microsoft Office applications
Preferred Qualifications
Experience working with:
Small molecules
Peptides
Biomolecules
PhD in:
Chemistry
Analytical Chemistry
Biochemistry
Related scientific discipline
Key Skills
LC-MS/MS Method Development
Bioanalytical Assays
Scientific Troubleshooting
Data Analysis & Interpretation
Regulatory Compliance (CAP/CLIA)
Technical Leadership
Client Interaction
Scientific Writing & Publications
Laboratory Automation
Presentation & Communication Skills
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