Senior Scientist I – Process Chemistry
Location: United States (On-site | Hybrid options depending on business needs)
Category: Process Chemistry | CMC | Drug Substance Development
Exelixis is seeking a Senior Scientist I, Process Chemistry to lead and execute in-house process development activities that support early-stage and preclinical research programs. This role focuses on evaluating synthetic routes, optimizing processes for scale-up, supporting drug substance manufacturing, and ensuring smooth technology transfer to contract manufacturing partners. The selected candidate will collaborate closely with medicinal chemists, CMC teams, and cross-functional stakeholders to deliver high-quality drug substance for ongoing projects.
Collaborate with discovery chemistry teams to assess and refine synthetic routes, enabling efficient scale-up of target compounds and key intermediates.
Conduct in-house process development, optimization, and troubleshooting to support timely delivery of material for preclinical studies.
Perform physical and chemical characterization of compounds, including solid-state assessments and polymorph screening to define stable DS polymorphs.
Prepare detailed process transfer documentation and technical packages for CMO/CRO partners.
Source and qualify appropriate starting materials in collaboration with project teams.
Support CMC regulatory activities, including drafting and reviewing regulatory filing sections as needed.
Work closely with Manufacturing, Formulation Development, Quality, Analytical Chemistry, and other internal teams to ensure high-quality and timely delivery of drug substance.
Stay updated on industry trends, scientific publications, and regulatory guidelines relevant to process chemistry and CMC development.
This role does not include direct supervisory duties.
Required Education:
Bachelor’s degree in Organic Chemistry, Chemical Engineering, Pharmaceutical Science, or related discipline with a minimum of 7 years of industry experience, or
Master’s degree in relevant fields with a minimum of 5 years of industry experience, or
PhD in relevant fields with 0+ years of experience, or
Equivalent combination of education and experience.
Experience Required:
Proven track record of delivering process chemistry results with high quality and scientific rigor.
Experience with solid-state characterization and polymorph screening is preferred.
Experience supporting or managing GMP manufacturing and CMO collaboration is a plus.
Strong expertise in process chemistry, synthetic organic chemistry, and analytical methods (NMR, MS, HPLC).
Understanding of physical–chemical properties, polymorphism, and compound characterization.
Demonstrated ability to design, optimize, and scale up drug substance manufacturing processes.
Excellent communication and interpersonal skills, with the ability to work cross-functionally.
Highly organized, detail-oriented, and capable of managing multiple priorities in parallel.
Self-motivated with the ability to work independently while maintaining alignment with project teams.
Exelixis offers a modern, collaborative, open-plan workspace designed to promote innovation and teamwork. Employees have access to ergonomic equipment and a supportive environment that enables high performance.
Base Salary Range: USD $116,000 – $165,500 annually, adjusted based on geographic region, experience, and internal equity.
Comprehensive Total Rewards package including:
401(k) with company contributions
Medical, dental, and vision insurance
Life and disability coverage
Flexible spending accounts
Annual discretionary bonus eligibility
Employee stock purchase program and long-term incentives
15 vacation days in the first year
17 paid holidays, including a December winter shutdown
Up to 10 annual sick days
Exelixis is an Equal Opportunity Employer committed to a workplace free from discrimination based on race, color, gender, age, national origin, religion, sexual orientation, gender identity, disability, veteran status, or any protected category.
This job description outlines the primary scope of responsibilities and qualifications and is not an exhaustive list of all duties associated with the position.
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China | Quarry Bay |Liaoning :
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