Senior Biostatistician / Senior Data Scientist / Analyst (Real-World Data) – US & UK Only
Location: Morrisville, North Carolina, United States (Open to candidates based in the US or UK only)
Job ID: 25105603-OTHLOC-1500-2DMA-2DR
Company: Syneos Health
About the Company
Syneos Health is a leading fully integrated biopharmaceutical solutions organization dedicated to accelerating clinical development, medical affairs, and commercialization outcomes. Operating across 110+ countries with approximately 29,000 professionals, the organization partners with global biopharma companies to streamline research, enhance real-world evidence generation, and bring therapies to market faster.
Over the past five years, Syneos Health has supported 94% of all novel FDA-approved drugs and 95% of EMA-authorized products, contributing to more than 200 studies across 73,000 sites and over 675,000 clinical trial patients worldwide.
Job Overview
Syneos Health is seeking an experienced Senior Biostatistician / Senior Data Scientist / Analyst to lead advanced Real-World Data (RWD) analytics initiatives. This role is ideal for professionals with deep expertise in biostatistics, observational research, healthcare databases, and advanced statistical programming.
The selected candidate will lead analysis strategy, develop technical specifications, execute complex statistical programming, and ensure methodological rigor across real-world evidence and outcomes research projects.
Applicants must be currently located in the United States or the United Kingdom. Visa sponsorship is not available.
Experience Required
Master’s degree in Biostatistics, Epidemiology, Data Science, Bioinformatics, or a related field with 5–8 years of relevant post-graduate experience
OR
PhD in a relevant discipline with a minimum of 3 years of post-doctoral professional experience
Additionally required:
Proven leadership in Real-World Data (RWD) analysis strategy and execution
Advanced expertise in statistical programming and observational research methodologies
Demonstrated experience managing cross-functional projects in matrix environments
Strong track record of delivering projects on time and meeting performance targets
Key Responsibilities
Lead development of statistical analysis strategies for Real-World Evidence (RWE) studies
Author and review technical specifications and statistical analysis plans
Develop, validate, and manage patient cohorts and key study variables
Conduct advanced statistical analyses using large healthcare datasets
Oversee quality control and ensure methodological rigor
Contribute to protocol development, manuscript preparation, and study design execution
Collaborate with epidemiology, HEOR, clinical, and commercial stakeholders
Track deliverables and project milestones using tools such as Jira or Azure DevOps (ADO)
Communicate complex statistical findings to non-technical stakeholders
Technical Skills and Analytical Expertise
Statistical Programming:
Advanced proficiency in SAS, R, and SQL (mandatory)
Python experience preferred
Ability to independently program, create reusable packages, and manage complex data structures
Advanced Analytical Methods:
Propensity score matching and causal inference techniques
Lines of therapy programming logic
Sankey diagram generation
Machine learning methodologies including LASSO, Decision Trees, Random Forest, and XGBoost
Application of machine learning models to Real-World Data
Data Platforms and Tools:
Experience with OHDSI or DARWIN toolsets in R
Familiarity with OMOP Common Data Model (CDM) or similar frameworks
Experience with cloud-based SQL environments (preferred)
Visualization tools such as Tableau or Power BI (advantageous)
Healthcare Data & Domain Expertise
Candidates should have hands-on experience with large-scale healthcare databases, including:
Claims Data Sources:
Optum
MarketScan
Pharmetrics+
HealthVerity
CPRD
Electronic Health Records (EHR):
IQVIA
Flatiron Health
ConcertAI
TriNetX
Additional expertise required:
Strong understanding of epidemiology and outcomes research
Experience with study design and real-world evidence execution
Exposure to biomarker and genomic datasets
Knowledge of US and international healthcare data sources
Experience with psychometric validation in clinical trial analyses (where applicable)
Specialized Experience (Preferred)
Oncology:
Oncology-focused observational research
Experience with Flatiron Health and ConcertAI datasets
Advanced programming logic for lines of therapy
Molecular Epidemiology:
Clinico-genomic multimodal data (e.g., Tempus AI)
Population biobank datasets (e.g., UK Biobank)
Experience in high-complexity matrix environments
Health Economics and Outcomes Research (HEOR):
Cost-effectiveness analysis
Burden of illness studies
Comparative effectiveness research
SAS/SQL required; R experience preferred
Compensation and Benefits
Syneos Health offers a competitive total rewards package designed to support professional growth and work-life balance. Benefits may include:
Medical, Dental, and Vision insurance
401(k) with company match
Employee Stock Purchase Plan
Performance-based bonus eligibility
Flexible paid time off and sick leave
Company car or car allowance (role dependent)
Compensation will be determined based on qualifications, expertise, geographic location, and applicable regulations.
Equal Opportunity Statement
Syneos Health is committed to equal employment opportunity and complies with all applicable federal, state, and international employment laws, including the Americans with Disabilities Act (ADA) and EU Equality Directives. Reasonable accommodations are provided where appropriate.
This Senior Biostatistician / Senior Data Scientist position presents an opportunity for experienced professionals to lead high-impact Real-World Evidence, healthcare analytics, and advanced biostatistics projects within a globally recognized biopharmaceutical organization.
Qualified candidates based in the US or UK are encouraged to apply through The Pharma Daily for global biostatistics and real-world data career opportunities.
Uttar Pradesh :
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Hajipur | Patna |Kerala :
Kannur | Kochi | Malappuram | Thiruvananthapuram | Trivandrum |Pondicherry (Puducherry) :
Pondicherry (Puducherry) |Jharkhand :
Ranchi |Sikkim :
Rangpo |India :
Siliguri |Illinois :
Abbott Park | Bloomingdale | Champaign | Chicago | Deerfield | Glenview | Lake Forest | Lombard | Naperville | Norridge | Park RIdge | Round Lake |Maryland :
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Anchorage | Barrow | Bethel | Juneau | Sitka | Wrangell |Massachusetts :
Andover | Billerica | Boston | Cambridge | Devens | Lexington | Massachusetts | Medford and Somerville | Rockland |Wisconsin :
Appleton | Kenosha | Pleasant Prairie | Portage | Waukesha |United states :
Arizona | Buffalo Grove | Clayton | Downers Grove | fairmont | Georgia | Keene | Michigan | Mt. Pleasant | New Jersy | OH | Piedmont | Salisbury | United States | Whitesboro | Winston-Salem |Georgia :
Atlanta | Augusta | Rome |Maine :
Bangor | Brewer |New Jersey :
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Chengdu | Garden city | Kansas City | Lawrence | McPherson |North Carolina :
Concord | Lumberton | North Carolina |Michigan :
Detroit | Houghton Lake | Macomb | Southfield |North Dakota :
Dickinson |Minnesota :
Duluth | Eden Prairie | Fridley | Hibbing | Maple Grove | Minneapolis and St. Paul, Minnesota. | Minnetonka | St.Paul |Kentucky :
Edgewood | Ft MItchell | Louisville | Shelbyville |Arkansas :
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Frank Scottile Blvd |Missouri :
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Basel | Zurich |Serbia :
Belgrade | Serbia |Hungary :
Budapest |BULGARIA :
Bulgaria | Vedant |Denmark :
Copenhagen | Denmark |Europe :
Europe | France | Latvia | Lendava | Leuven | Poland | Slovenia | Spain |Finland :
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Swords |Republic of China :
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China | Quarry Bay |Liaoning :
Dalian |Zhejiang :
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Wuhan |Capital of Netherland :
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Arkansas | Remote Australia |New South Wales :
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Nedlands |Queensland :
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England | Harlow | Leeds | London | Maidenhead | Salt Lake City | Stevenage | Stirling | United Kingdom |North Yorkshire :
Harrogate |South Yorkshire :
Sheffield |Oxfordshire :
Witney |Ontario :
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Be'Er Sheva | Tel Aviv | Yavne | Kfar Saba | Netanya |Remote :
Medan | Belgium | Minnesota | Nairobi | Green Way | Remote - Europe | Hammond | Regulatory Labeling Manager (NA and LATAM Only) | Hungary | Springville | Bishop | Zaragoza | Xzagreb | Victoria | Switzerland | Tulsa | McFarland | Remote - Middle East | Lousiana | Melbourne | Riga | Leinster | Remote | Lenexa | Remote - South America (Latin Americal) | Thailand | Bountiful | French | Castlebar | Texas | Remote - Africa | Ireland | Manipal | Blue Bell | Faridabad | Remote, USA | Slovakia |Republic of Colombia :
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Cairo |Mexico :
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King Abdullah Economic City | Riyadh | Jeddah | Najran | Rabigh | Khulais |Kuala Lumpur :
Kuala Lumpur |Kyiv Oblast :
Kyiv |Lima Region :
Lima |France :
Lyon | Paris |South Africa :
Midrand | South Africa |Nišava District :
Niš |Bohemia :
Prague |Chile :
Santiago |Bosnia and Herzegovina :
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Sofia |Sweden :
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