Senior Site Contracts Specialist – Hybrid (Morrisville, NC, USA)
Updated: December 3, 2025
Location: USA–NC–Morrisville (Hybrid)
Job ID: 25103631
Company: Syneos Health
About the Role
Syneos Health is seeking an experienced Senior Site Contracts Specialist to support site identification, site contracting, and documentation activities for global clinical research programs. This role is essential for ensuring efficient and compliant start-up processes across investigative sites. Positioned within a hybrid work model in Morrisville, North Carolina, this role requires strong regulatory understanding, exceptional negotiation capabilities, and the ability to manage site-level documents with precision.
You will collaborate with cross-functional clinical operations teams, serve as the primary contact for investigative sites, and contribute to process improvements that enhance operational excellence within the Site Start-Up function.
Key Responsibilities
Manage and execute end-to-end site identification processes in alignment with regulations, SOPs, and project-specific requirements.
Review, negotiate, and finalize Site Confidentiality Agreements (CDAs) and Site Information Forms (SIFs) while maintaining high accuracy and professionalism.
Maintain and analyze site performance metrics; identify challenges, propose solutions, and implement corrective actions as needed.
Serve as the main point of contact for investigative sites throughout the identification and qualification stages.
Track site identification progress and ensure complete collection and filing of required documentation.
Contribute to the development and improvement of internal processes, policies, and programs.
Support project execution by managing defined components of assigned studies or functional areas.
Mentor and support junior staff or team members when applicable.
Collaborate with cross-functional teams to ensure seamless flow of information and efficient site start-up operations.
Ensure strict compliance with relevant regulations, SOPs, and quality standards.
Qualifications
Bachelor’s degree in a relevant discipline or equivalent professional experience.
Strong working knowledge of clinical research regulations, SOPs, and guidelines related to site identification and start-up.
Proven experience negotiating CDAs, SIFs, and other site-required documents.
Excellent communication, stakeholder management, and negotiation skills.
Ability to analyze and report site performance metrics accurately.
Proficiency in site management tools, document tracking systems, and MS Office.
Experience Required
Minimum 4–6 years of experience in clinical operations, site start-up, site contracting, or related roles within CROs or pharmaceutical companies.
Experience managing site identification workflows for multi-site or global clinical trials.
Demonstrated experience handling CDA/SIF negotiations and site documentation coordination.
Prior experience in a hybrid or cross-functional work environment preferred.
Core Skills
Strong organizational and time management abilities.
Ability to prioritize multiple projects and meet timelines.
Detail-oriented with strong analytical and problem-solving skills.
Ability to work both independently and within collaborative project teams.
Proficiency with site management and document tracking platforms.
Salary Range
$56,400 – $95,900
Salary may vary based on experience, qualifications, skills, and individual performance factors.
Benefits Offered
Syneos Health provides a diverse benefits program, which may include:
Medical, Dental, and Vision coverage
Company-matched 401(k)
Employee Stock Purchase Plan participation
Performance-based bonuses
Company car or car allowance (role-dependent)
Flexible paid time off and sick leave
Additional benefits based on individual work location and local regulations
About Syneos Health
Syneos Health is a global, integrated biopharmaceutical solutions organization with more than 29,000 employees across 110 countries. The company has contributed to:
94 percent of Novel FDA-Approved Drugs
95 percent of EMA-Authorized Products
Over 200 studies conducted across 73,000 sites and 675,000+ trial participants
With a focus on innovation, collaboration, and operational excellence, Syneos Health supports the advancement of new therapies that improve patient outcomes worldwide.
Role Summary
The Senior Site Contracts Specialist plays a vital role in executing site identification, coordinating site-level agreements, and maintaining compliance-driven documentation. The position contributes to the efficiency and success of clinical trials by ensuring accurate, timely, and regulatory-compliant start-up processes.
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