Senior Scientist – SBX Molecular Engineering
Location: Seattle, Washington, United States of America
Category: Research & Development
Job Type: Full-Time
Job ID: 202512-130938
About the Role
Roche is advancing science to provide meaningful improvements in healthcare globally. Following the acquisition of Stratos Genomics in 2020, Roche Diagnostics is pioneering Sequencing by Expansion (SBX™) technology, which enhances DNA sequencing accuracy and throughput. As a Senior Scientist in the Molecular Engineering group, you will design, synthesize, and optimize molecular building blocks that translate DNA sequences into measurable surrogates, the Xpandomer, supporting next-generation sequencing innovations.
Key Responsibilities
Lead the research, design, and execution of innovative, well-controlled experiments with high precision.
Mentor, guide, and collaborate with cross-functional teams to achieve project milestones.
Troubleshoot complex experimental challenges using creative solutions.
Develop Standard Operating Procedures (SOPs) for reagent and starting material production.
Participate actively in reagent synthesis, characterization, and protocol development.
Maintain accurate, detailed, and compliant laboratory records.
Analyze experimental data and present findings in group or departmental meetings.
Propose and implement process improvements to enhance lab operations and experimental outcomes.
Maintain laboratory organization, safety, and compliance standards.
Qualifications & Experience Required
PhD in Organic Synthesis, Chemistry, Chemical Engineering, Biochemistry, or related field with 4+ years of relevant industrial or academic laboratory experience, or
Master’s degree in the same fields with 7+ years of experience, or
Bachelor’s degree with 8+ years of relevant laboratory experience.
Strong expertise in nucleotide/heterocyclic chemistry, phosphorus chemistry, and multi-step organic synthesis.
Experience with chemical and biochemical sample handling, reactivity assessment, purification, and storage.
Hands-on experience with analytical techniques such as HPLC, MS, NMR, automated DNA synthesizers, inert atmosphere work, and manual pipetting.
Prior exposure to next-generation DNA sequencing technologies is highly desirable.
Preferred Skills
Demonstrated ability in the chemistry of nucleotides, phosphoramidites, heterocycles, amino acids, and bio-conjugations.
Strong problem-solving, critical thinking, and data interpretation skills.
Ability to work in a collaborative, fast-paced research environment and mentor junior scientists.
Additional Information
Relocation support is available.
Salary range for Seattle, WA: $104,400 – $193,800 annually, dependent on experience, qualifications, and geographic location.
Discretionary annual bonus based on individual and company performance.
Comprehensive benefits including medical, dental, vision, and retirement plans.
Application Requirement
Please include a cover letter detailing your interest in SBX technology, why you want to work with Roche, and how your expertise will contribute to advancing molecular engineering initiatives.
About Roche
Roche is committed to transforming healthcare through innovation, advancing science, and ensuring access to diagnostics and medicines worldwide. With over 100,000 employees globally, we deliver life-changing healthcare solutions, empowering people to live healthier lives. Roche is an equal opportunity employer.
Roche is committed to providing reasonable accommodations for applicants with disabilities.
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