Senior Scientist II – Biologics Purification
Location: North Chicago, Illinois, United States
Function: Research & Development – Biologics Discovery Sciences
Employment Type: Full-Time
Job ID: R00138816
Experience Required: 4–12+ years (based on qualification level)
Travel Requirement: Up to 5%
About the Company
AbbVie is a global, research-focused biopharmaceutical leader dedicated to discovering and delivering innovative medicines that address serious diseases and future healthcare challenges. With a strong portfolio across immunology, oncology, neuroscience, eye care, and aesthetics, AbbVie combines cutting-edge science with a commitment to integrity, innovation, and patient impact worldwide.
Job Overview
AbbVie is seeking a Senior Scientist II – Biologics Purification to join its Biologics Discovery Sciences team in North Chicago, IL. This role is critical to advancing next-generation biologic and bispecific antibody therapies by delivering high-purity drug candidates that support both in vitro and in vivo research programs.
The successful candidate will provide scientific leadership in purification process development, apply advanced chromatography and bioprocessing techniques, and collaborate across multidisciplinary teams to accelerate biologics discovery and development.
Key Responsibilities
Lead purification and downstream processing of bispecific and complex biologic molecules to support discovery and preclinical development
Design and execute robust purification and process development strategies with scalability considerations for future manufacturing
Apply advanced chromatography, filtration, and large-scale bioprocessing techniques to optimize yield, purity, and product quality
Utilize Design of Experiments (DOE), in silico modeling, and predictive tools to optimize protein separation and process performance
Integrate, analyze, and manage analytical and process data using LIMS, ETL tools, SDMS platforms, and data extraction APIs
Collaborate closely with cross-functional teams, translating molecular and biophysical insights into actionable purification solutions
Ensure rigorous scientific documentation, data integrity, and compliance with internal quality standards
Present scientific findings and process strategies to technical and non-technical stakeholders
Stay current with emerging literature, technologies, and industry best practices to drive innovation and continuous improvement
Required Qualifications & Experience
Bachelor’s, Master’s, or PhD in Bioinformatics, Biophysics, Chemical Engineering, Biochemistry, or a related scientific discipline
Experience requirements by degree level:
Bachelor’s degree: typically 12+ years of relevant industry experience
Master’s degree: typically 10+ years of relevant industry experience
PhD: typically 4+ years of relevant industry experience
Deep expertise in large-scale biologics purification and downstream bioprocessing
Strong proficiency with chromatography and bioprocess software and tools, such as UNICORN, Chromeleon, Empower, JMP, Minitab, Python, and SDMS platforms
Demonstrated experience applying DOE and in silico modeling to predict and optimize protein separation behavior
Solid understanding of biologic molecular characteristics and post-translational modifications
Experience with data integration, ETL workflows, APIs, and LIMS platforms is highly desirable
Excellent analytical, problem-solving, communication, and presentation skills
Proven ability to work independently and collaboratively in a fast-paced, multidisciplinary research environment
Compensation & Benefits
Pay Range: USD 106,500 – 202,500 (base salary; varies by location and experience)
Eligibility for short-term and long-term incentive programs
Comprehensive benefits package including paid time off, holidays, medical, dental, vision insurance, and 401(k) plans
Compensation and benefits are subject to eligibility and company discretion in accordance with applicable laws
Why Join AbbVie
Contribute directly to the discovery of transformative biologic therapies
Work in a science-driven, innovation-focused research environment
Collaborate with leading experts across biologics discovery and development
Advance your career while making a meaningful global impact on patient health
Equal Opportunity & Compliance
AbbVie is an equal opportunity employer committed to diversity, inclusion, and ethical business practices. Qualified applicants will receive consideration without regard to race, gender, disability, veteran status, or other protected characteristics.
Recruitment Fraud Notice
AbbVie does not request any form of payment or sensitive personal information during the recruitment process. Candidates are advised to verify the authenticity of all recruitment communications.
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