Job Title: Senior Scientist – Assay Development & Intestinal In Vitro Models
Company: Novartis Institutes for BioMedical Research, Inc.
Location: Cambridge, Massachusetts, USA (Onsite)
Job Type: Full-Time | Senior Level | Research & Development
Job ID: REQ-10067218
About Novartis:
Novartis is a global leader in biomedical research and pharmaceutical innovation, dedicated to discovering, developing, and delivering transformative therapies for patients worldwide. Our mission is to advance science through cutting-edge research, collaborative culture, and evidence-driven decision-making.
Role Overview:
The Senior Scientist – Assay Development & Intestinal In Vitro Models will contribute to target discovery and validation for inflammatory diseases by designing and executing advanced in vitro assays. The role leverages human cell models, cutting-edge -omics approaches, and cellular assays to drive innovative therapeutic research. The successful candidate will collaborate across cross-functional teams to deliver high-quality, reproducible research outcomes.
Key Responsibilities:
Design, develop, and execute biological assays and intestinal in vitro models to explore and validate novel drug targets.
Conduct mechanism-of-action studies using molecular biology, cell signaling, immunology, and cellular biology techniques.
Engineer human cell models (e.g., CRISPR) for functional screening and mechanistic studies.
Collaborate with cross-functional teams, analyze data, document experiments, and communicate results effectively.
Mentor and train junior scientists, fostering knowledge sharing and laboratory excellence.
Stay updated with scientific literature and advancements, contribute to publications, and present findings at conferences.
Required Experience & Qualifications:
B.S./M.S. in Biological or Biomedical Sciences with 7+ years of hands-on experience; Ph.D. graduates (<2 years) will also be considered.
Proven experience in in vitro cell-based assays using cell lines, primary cells, stem cells/iPSCs. Experience with intestinal organoids, spheroids, barrier models, and co-cultures preferred.
Strong expertise in molecular biology, cell signaling, and immunology, preferably in inflammatory disease research.
Proficiency in experimental design, troubleshooting, data analysis, and statistical/bioinformatics tools.
Excellent written and verbal communication, organizational, and interpersonal skills.
Ability to work independently and collaboratively in a dynamic, fast-paced research environment.
Desirable Skills:
Experience with inflammation research, particularly Inflammatory Bowel Disease (IBD) therapeutic discovery.
Functional studies using primary human or rodent cells and ex vivo tissue assays.
Familiarity with advanced omics technologies (e.g., spatial transcriptomics, single-cell RNA-seq) and computational biology or machine learning approaches.
Demonstrated track record of scientific publications and conference presentations.
Compensation & Benefits:
Senior Scientist I: $85,400 – $158,600 per year
Senior Scientist II: $93,800 – $174,200 per year
Performance-based cash incentives and potential eligibility for annual equity awards.
Comprehensive benefits including health, life, disability insurance, 401(k) with company contribution, and generous paid time off.
Why Join Novartis:
Drive therapeutic innovation in inflammatory disease research using cutting-edge scientific approaches.
Collaborate with a global network of experts in a dynamic, purpose-driven environment.
Access career development, mentorship, and opportunities for scientific growth.
Contribute to a culture that values excellence, collaboration, and innovation.
Equal Opportunity & Accessibility:
Novartis is an Equal Opportunity Employer and provides reasonable accommodations for individuals with disabilities. We do not discriminate based on legally protected characteristics.
Apply Now
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