Job Title: Senior Scientist, Radiochemistry
Location: Los Angeles, California, United States
Updated: October 17, 2025
Company: Telix Pharmaceuticals
About Telix Pharmaceuticals
Telix Pharmaceuticals is a dynamic, fast-growing radiopharmaceutical company with offices in Australia (HQ), Belgium, Japan, Switzerland, and the United States.
Our mission is to deliver on the promise of precision medicine through targeted radiation.
We aim to improve the quality of life for people living with cancer and rare diseases by developing advanced radiopharmaceutical products.
In this role, you will support the global launch of our prostate cancer imaging agent and help drive our pipeline of late-stage clinical products addressing significant unmet needs in oncology and rare diseases.
Position Overview
The Senior Scientist, Radiochemistry will perform hands-on laboratory work involving radiolabeling of antibodies and antibody fragments with radiometals and conjugation of biomolecules with metal chelators.
This position requires expertise in radiochemistry, protein biochemistry, and antibody characterization, supporting preclinical research, theranostic applications, and early CMC scale-up initiatives.
Additionally, the role includes serving as the Radiation Safety Officer (RSO) to ensure regulatory compliance and safe laboratory practices.
Key Responsibilities
1. Radiochemistry & Conjugation
Perform and optimize radiolabeling of antibodies and antibody fragments with diagnostic and therapeutic radiometals (e.g., 177Lu, 225Ac, 89Zr, 64Cu).
Conduct chemical conjugation of antibodies with metal chelators (e.g., DOTA, DOTAGA, DTPA, DFO, MACROPA).
Develop reproducible, scalable labeling protocols for preclinical and translational studies.
Design and execute quality control assays (HPLC, iTLC, SEC, SDS-PAGE).
Develop and transfer analytical methods to support preclinical and CMC activities.
2. Protein Biochemistry
Handle, purify, and characterize antibodies and proteins.
Assess protein integrity and stability after conjugation and radiolabeling.
Support analytical method development for protein–radiometal conjugates.
3. Preclinical & Development Support
Collaborate with the in-vivo biology team to support both in vitro and in vivo studies.
Contribute to CMC scale-up and IND-enabling documentation.
Participate in process documentation and technology transfer efforts.
4. Radiation Safety
Serve as the site’s Radiation Safety Officer (RSO).
Ensure compliance with local, state, and federal radiation safety regulations.
Implement safety procedures, train laboratory personnel, and maintain records and licenses.
Education & Experience
Required Qualifications
Bachelor’s degree + 8+ years of experience, OR
Master’s degree + 6+ years of experience, OR
Ph.D. + 5+ years of experience in Chemistry, Biochemistry, Radiochemistry, Pharmaceutical Sciences, or related fields.
Minimum 3 years’ hands-on experience in:
Radiolabeling of biologics
Metal chelator chemistry
QC methods and protein characterization
Strong background in protein biochemistry (antibody purification, conjugation, and analysis).
Experience with HPLC, SEC, SDS-PAGE, and iTLC.
Prior or current qualification as Radiation Safety Officer (RSO) or equivalent experience.
In-depth knowledge of radiation safety regulations.
Strong documentation, organization, and communication skills.
Preferred Qualifications
Experience in preclinical radiopharmaceutical development (oncology).
Familiarity with CMC scale-up and regulatory documentation.
Experience in GMP/GLP environments.
Core Competencies & Behaviors
Safety Mindset: Adheres to radiation safety protocols and lab best practices.
Scientific Rigor: Designs, executes, and analyzes experiments with precision.
Collaboration: Works effectively across multidisciplinary teams.
Accountability: Takes ownership and delivers on commitments.
Adaptability: Adjusts to changing project and regulatory priorities.
Problem-Solving: Approaches technical challenges with creativity and persistence.
Communication: Clearly communicates results, documentation, and regulatory data.
Why Join Telix?
At Telix, we believe everyone counts, we strive to be extraordinary, and we pursue goals with determination and integrity.
You’ll be part of a supportive, interdisciplinary global team working to deliver the next generation of precision medicines.
Employee Benefits:
Competitive salary
Annual performance-based bonuses
Equity-based incentive programs
Generous vacation and wellness days
Professional learning and development opportunities
Flexible hybrid and remote work options
Equal Opportunity Statement
Telix Pharmaceuticals is an equal opportunity employer.
All qualified applicants are considered without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, or other protected categories.
How to Apply
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