Senior Research Investigator – Translational Bioinformatics & Disease Biology
Location: Bangalore, Karnataka, India
Experience Required: Ph.D. with 2+ years postdoctoral or industry experience in translational bioinformatics, computational biology, or related fields
Division: Dedicated Centre – Translational Medicine, Bristol Myers Squibb Biocon Research Centre
Company: Syngene International Ltd. / Biocon BMS Research Centre
About the Role:
Syngene International, in collaboration with Bristol Myers Squibb, is seeking a Senior Research Investigator / Senior Scientist to join the Translational Medicine team at the Biocon Research Centre in Bangalore. This role integrates bioinformatics, computational biology, and laboratory-based translational research to provide actionable insights across multiple therapeutic areas, including oncology, immunology, hematology, and neuroscience. The candidate will lead cross-functional teams and apply multi-omics and AI/ML methodologies to accelerate drug discovery and development.
Key Responsibilities:
Design, implement, and oversee bioinformatics strategies for preclinical and clinical translational studies.
Integrate and analyze multi-omics datasets (WES/WGS, bulk and single-cell RNA-seq, ATAC-seq, spatial transcriptomics, proteomics, flow cytometry) to discover biomarkers and inform patient selection strategies.
Develop and apply machine learning and AI models for predictive analytics, feature selection, and multi-modal data integration.
Collaborate with biomarker scientists, clinical teams, and research centers to support target prioritization, trial hypothesis generation, and therapeutic strategy.
Ensure reproducibility and scalability of NGS and bioinformatics pipelines, utilizing tools such as samtools, picard, and R/Bioconductor.
Support experimental design and data generation for mechanism-of-action studies, combination therapy rationale, resistance mechanisms, and differentiation from standard of care.
Contribute to preclinical collaborations, prepare study reports, and communicate findings to internal stakeholders, regulatory authorities, and external scientific audiences.
Anticipate technical or experimental challenges and provide strategic solutions to ensure project success.
Maintain a strong publication record and apply insights from current literature to complex scientific questions.
Qualifications & Experience:
Ph.D. in Bioinformatics, Computational Biology, Genetics, or related discipline; M.Sc./M.Tech./M.Eng. with 3+ years relevant experience may be considered.
2+ years of relevant postdoctoral or industry experience in informatics or translational medicine, preferably in oncology, immunology, hematology, or neuroscience.
Technical & Professional Skills:
Hands-on experience with RNASeq, DNASeq, and NGS workflows; proficiency with samtools, picard, and other NGS tools.
Expertise in high-throughput molecular data analysis, single-cell technologies, proteomics, and flow cytometry.
Advanced programming in R and Python, including data visualization (ggplot2) and reproducible research in Linux HPC or AWS cloud environments.
Experience in machine learning, AI, predictive modeling, and deep learning applications for multi-omics data.
Strong statistical background, experimental design knowledge, and ability to interpret complex datasets.
Laboratory awareness in cell culture, primary cell isolation, transfection, RNA/DNA sequencing, epigenomic assays, protein assays, and cell phenotyping.
Excellent communication, team leadership, and cross-functional collaboration skills.
Behavioral Competencies:
Self-motivated, proactive, and detail-oriented.
Strong commitment, enthusiasm, and drive to deliver impactful scientific results.
Ability to work in a fast-paced, dynamic, and collaborative environment.
About Syngene International:
Syngene International Ltd. is a leading global organization delivering integrated scientific solutions across pharmaceutical, biotechnology, nutrition, animal health, consumer goods, and specialty chemical sectors. With over 4,000 scientists, Syngene collaborates with global leaders including Bristol-Myers Squibb, Baxter, Amgen, GSK, Merck KGaA, and Herbalife to address complex scientific challenges, enhance R&D productivity, accelerate time-to-market, and reduce the cost of innovation.
Equal Opportunity Employer:
Syngene is committed to equal employment opportunity and provides reasonable accommodations for qualified individuals with disabilities. Applications are welcomed from all qualified candidates, irrespective of age, gender, race, religion, disability, or other legally protected characteristics.
Application Instructions:
Interested candidates should submit their CV and cover letter via the Syngene careers portal, highlighting relevant experience and motivation for the role.
Gujarat :
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Banasthali | Bhiwadi | Jaipur | Pilani | Udaipur |Karnataka :
Bangalore | Belgaum | Bengaluru | B.G Nagara | Bommasandra | Colorado | Czech Republic | Karnataka | Mangaluru | Mysore | Udupi |Punjab :
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Dehradun | Halifax | Nainital | Rishikesh | Roorkee |Delhi :
Delhi | India | New Delhi | PAN-India |Assam :
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Hajipur | Patna |Kerala :
Kannur | Kochi | Malappuram | Thiruvananthapuram | Trivandrum |Pondicherry (Puducherry) :
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Rangpo |India :
Siliguri |Illinois :
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Appleton | Kenosha | Pleasant Prairie | Portage | Waukesha |United states :
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Frank Scottile Blvd |Missouri :
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Hawai | kentucky | Sylmar | Woonsocket |Nebraska :
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Berlin |Baden-Wurttemberg :
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Frankfurt | Harveysburg |Germany :
Germany | GErmany |Lower Saxony :
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Ingelheim am Rhein | Mainz |Schleswig Holstein :
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Saarbrucken |Switzerland :
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Europe | France | Latvia | Lendava | Leuven | Poland | Slovenia | Spain |Finland :
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Hangzhou |Tokiyo :
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Wuhan |Capital of Netherland :
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Netherlands |Remote Australia :
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England | Harlow | Leeds | London | Maidenhead | Salt Lake City | Stevenage | Stirling | United Kingdom |North Yorkshire :
Harrogate |South Yorkshire :
Sheffield |Oxfordshire :
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Tartu | Estonia |Harju County (Maakond) :
Tallinn |Hà Nội :
Hanoi | Hà Nội |Ho Chi Minh :
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Kuala Lumpur |Kyiv Oblast :
Kyiv |Lima Region :
Lima |France :
Paris | Lyon |South Africa :
Midrand | South Africa |Nišava District :
Niš |Bohemia :
Prague |Chile :
Santiago |Bosnia and Herzegovina :
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