Job Title: Principal Scientist – Translational Sciences
Company: Syngene International Ltd.
Location: Bengaluru, Karnataka, India – 560100
Department: Translational and Clinical Research
Division: Discovery Services
Job Type: Full-Time
Experience Required: 8–12 Years
Education: Master’s degree in Molecular Biology, Biotechnology, Translational Sciences, or a related life sciences discipline
About Syngene
Syngene International Ltd. is an innovation-led contract research, development, and manufacturing organization (CRDMO) providing integrated scientific services from early discovery through commercial manufacturing. The company collaborates with global pharmaceutical, biotechnology, and healthcare organizations to accelerate drug discovery, development, and commercialization.
Headquartered in Bengaluru, India, Syngene delivers world-class research capabilities across discovery biology, translational research, clinical development, and manufacturing, while maintaining strong compliance with international regulatory and quality standards.
Job Summary
Syngene is seeking an experienced professional for the role of Principal Scientist – Translational Sciences within the Translational and Clinical Research department. The position focuses on leading clinical biomarker studies and translational research projects utilizing advanced technologies such as flow cytometry, next-generation sequencing (NGS), and other molecular biology platforms.
The role involves leading biomarker assay development, sample analysis, data interpretation, and scientific reporting in compliance with GLP and GCLP guidelines. The Principal Scientist will collaborate with cross-functional research teams, ensure regulatory compliance, and contribute to translational research strategies that support clinical development programs.
Key Responsibilities
Lead end-to-end execution of biomarker studies conducted under GLP and GCLP standards, including study planning, assay development, validation, sample analysis, and final reporting.
Design, optimize, and troubleshoot advanced flow cytometry panels for immunophenotyping and receptor occupancy assays.
Develop and implement next-generation sequencing workflows including RNA sequencing and targeted sequencing assays.
Ensure strict adherence to established Standard Operating Procedures, regulatory requirements, and data integrity standards.
Collaborate with Quality Control and Quality Assurance teams for study reviews, deviation management, and regulatory audit readiness.
Prepare and review scientific and technical documentation including protocols, assay development reports, validation reports, and final study reports.
Interpret experimental data and contribute to scientific discussions, project reviews, and cross-functional team meetings.
Communicate study outcomes and technical insights to internal stakeholders, collaborators, and clients.
Mentor and guide junior scientists in biomarker assay development, laboratory instrumentation, troubleshooting methodologies, and regulatory compliance practices.
Support continuous improvement of laboratory processes and research methodologies in translational sciences.
Safety and Compliance Responsibilities
Ensure strict adherence to environmental, health, and safety (EHS) policies and laboratory safety procedures.
Promote safe laboratory practices and compliance with organizational quality standards.
Complete all mandatory training related to data integrity, safety protocols, and regulatory compliance.
Maintain adherence to Syngene’s quality management systems and operational procedures.
Required Skills and Competencies
Advanced expertise in clinical flow cytometry including immunophenotyping and receptor occupancy assays.
Strong technical knowledge of RNA isolation, quality control processes, and NGS library preparation for sequencing workflows.
Experience with biomarker assay platforms including qPCR, immunohistochemistry (IHC), and ELISA.
Strong scientific problem-solving and analytical skills in translational research environments.
Excellent organizational and project management skills with the ability to manage multiple biomarker studies simultaneously.
Strong written and verbal communication skills with the ability to present complex scientific data clearly.
Ability to work effectively under time-sensitive conditions within multidisciplinary research teams.
Experience Required
Candidates should possess 8–12 years of experience in translational research, clinical biomarker assays, or related CRO or clinical research environments. Hands-on expertise in clinical flow cytometry and next-generation sequencing workflows is essential. Experience working within GLP/GCLP-compliant laboratories and regulatory-driven research environments is highly preferred.
Syngene Core Values
All employees at Syngene are expected to demonstrate alignment with the organization’s core values:
Excellence
Integrity
Professionalism
Equal Opportunity Statement
Syngene International Ltd. is an equal opportunity employer committed to providing fair employment opportunities to all individuals regardless of age, gender, race, disability, religion, nationality, sexual orientation, or any other protected characteristic under applicable law. The company also provides reasonable accommodations for qualified individuals with disabilities during the recruitment process.
Uttar Pradesh :
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Siliguri |Illinois :
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