Job Title: Lead Scientist – Synthetic Chemistry
Job Category: Discovery Chemistry / Medicinal Chemistry
Location: Bangalore, Karnataka, India
Experience Required: 6–9 Years
Job Type: Full-Time
Company Overview
Syngene International Ltd. is a global, innovation-driven contract research, development, and manufacturing organization (CRDMO) providing integrated scientific services from early discovery to commercial supply. Syngene partners with leading pharmaceutical and biotechnology companies worldwide to accelerate drug discovery and development while maintaining high standards of safety, quality, and compliance.
Role Overview
The Lead Scientist – Synthetic Chemistry will be responsible for independently designing synthetic schemes, executing organic synthesis reactions, and delivering high-quality compounds with fast turnaround times. The role demands problem-solving expertise, strong analytical interpretation skills, and the ability to lead and mentor junior scientists in a CRO setting.
Key Responsibilities
Design synthetic schemes for target molecules, proactively identifying potential bottlenecks and implementing mitigation strategies.
Perform synthetic reactions, workups, purification (column chromatography, crystallization, re-crystallization, preparative TLC) and operate laboratory equipment efficiently.
Deliver final compounds on schedule while meeting Syngene’s productivity metrics (# of compounds/month, # of steps/month, productivity index ~1.5) without compromising quality or safety.
Record experimental observations and results in compliance with Electronic Laboratory Notebook (ELN) policies.
Coordinate sample analysis, document findings, and communicate progress to supervisors or group leaders.
Demonstrate advanced analytical interpretation and purification expertise to ensure compound quality.
Maintain awareness of chemical hazards, SDS, emergency procedures, and EHS-compliant waste segregation.
Follow all safety, quality, and confidentiality protocols rigorously.
Utilize literature search engines and predictive synthesis tools to support project planning and execution.
Mentor junior team members and contribute to the overall development of the synthetic chemistry team.
Experience Required
6–9 years of experience in synthetic chemistry within a CRO or pharmaceutical discovery environment.
Proven ability to design synthetic schemes and independently troubleshoot complex synthesis problems.
Educational Qualification
M.Sc. in Organic Chemistry or General Chemistry.
Technical Skills
Strong knowledge of organic synthesis and reaction mechanisms.
Expertise in purification techniques and analytical interpretation.
Familiarity with laboratory apparatus and instrumentation relevant to synthetic chemistry.
Competency in predictive synthesis tools and literature-based research.
Behavioral & Functional Skills
Proactive, detail-oriented, and safety-conscious.
Strong problem-solving, decision-making, and mentoring skills.
Ability to manage multiple projects, prioritize tasks, and work in a dynamic CRO environment.
Effective communication and collaboration with cross-functional teams.
Core Values Alignment
All employees are expected to demonstrate Syngene’s core values consistently: Excellence, Integrity, and Professionalism.
This role offers an opportunity to lead synthetic chemistry projects in a fast-paced, innovation-driven environment, contributing to cutting-edge drug discovery efforts on a global scale.
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