Job Title: In Vitro ADME Scientist
Location: Hyderabad (Kolthur, Shamirpet, Medchal), Telangana, India
Division: Discovery Services
Department: Discovery Biology
Syngene International Ltd., established in 1993, is a globally recognized discovery, development, and manufacturing organization offering integrated scientific services to the pharmaceutical, biotechnology, nutrition, animal health, consumer goods, and specialty chemical industries. Our clientele includes industry leaders such as Bristol-Myers Squibb, Amgen, Baxter, GSK, Merck KGaA, and Herbalife. With a team of over 4,240 scientists, we combine innovation, technical expertise, and operational excellence to accelerate drug discovery, improve R&D productivity, and lower the cost of innovation.
The In Vitro ADME Scientist will support drug discovery and development projects by conducting high-quality in vitro metabolism assays to evaluate the ADME properties of small molecules. This role involves executing liver microsome and CYP inhibition studies, managing laboratory operations with automation platforms, and ensuring strict compliance with safety and quality standards.
Plan, execute, and troubleshoot in vitro metabolism assays using human liver microsomes.
Conduct single-point inhibition, reversible CYP IC₅₀ inhibition, and TDI-IC₅₀ shift assays.
Prepare Standard Operating Procedures (SOPs) and Experimental Operating Procedures (EOPs).
Record and report study results accurately and on time in cross-functional team meetings.
Maintain high standards of laboratory housekeeping and ensure compliance with EHS guidelines.
Collaborate effectively with cross-functional teams to support multiple high-volume projects.
Operate liquid handling systems and automation platforms efficiently.
M.Pharm in Pharmaceutical Sciences or M.Sc in Biological Sciences.
Strong knowledge of in vitro ADME assays and DMPK principles.
Proficiency in data analysis software such as Microsoft Excel and GraphPad Prism.
Experience with automation platforms is desirable.
Ability to troubleshoot and optimize assay performance.
Foundational industrial experience in DMPK/ADME research is preferred.
Demonstrated experience in conducting and interpreting in vitro metabolism studies.
Strong team player with cross-functional collaboration skills.
Ability to deliver study reports on time and adapt to dynamic lab environments.
Effective communication skills for presenting study results in meetings.
Commitment to scientific excellence and adherence to quality and safety standards.
Evidence of contributions to peer-reviewed publications is desirable.
Work at a globally recognized CRO with exposure to cutting-edge drug discovery projects.
Contribute to projects with industry-leading pharmaceutical clients.
Gain hands-on experience with automation, ADME assays, and cross-functional research.
Grow professionally in a collaborative and innovative work environment.
Syngene provides equal employment opportunities (EEO) to all persons regardless of age, gender, disability, nationality, religion, sexual orientation, or other legally protected characteristics. Reasonable accommodations are provided for qualified individuals with disabilities.
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